Nilotinib Impurity 42 CAS CATO-C4X-125642
| CAS No. | CATO-C4X-125642 |
| Molecular Formula | C24H17BrF3N5O |
| Molecular Weight | 528.32 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Nilotinib Impurity 42 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Nilotinib Impurity 42 (CAS CATO-C4X-125642) is a certified pharmaceutical impurity reference standard with the molecular formula C24H17BrF3N5O and a molecular weight of 528.32 g/mol.
Nilotinib Impurity 42 (C24H17BrF3N5O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C24H17BrF3N5O |
| Molecular Weight | 528.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 5 |
Related Nilotinib Standards
- Nilotinib Hydrochloride Monohydrate EP Impurity H (CAS 641571-15-5)
- Nilotinib (CAS 641571-10-0)
- Nilotinib Impurity 9 (CAS 641571-05-3)
- Nilotinib-d3 (CAS 1215678-43-5)
- Nilotinib-d6 (CAS 1268356-17-7)
- Nilotinib EP Impurity E (CAS 2119583-26-3)
- Nilotinib Impurity 43 (CAS CATO-C4X-125643)
- Nilotinib Hydrochloride Monohydrate EP Impurity F (CAS 2119583-24-1)
Recommended Standards
- Pyriminostrobin (CAS 1257598-43-8)
- Capstone product A (CAS 80475-32-7)
- 2,7-Dibromo-9,9-bis(2-(2-methoxyethoxy)ethyl)-9H-fluorene (CAS 180690-29-3)
- 4-((4-Bromophenyl)(hydroxy)methylene)-1-(5-(tert-butyl)oxazol-3(2H)-yl)-5-(4-nitrophenyl)pyrrolidine-2,3-dione (CAS 5667-64-1)
- Mosapride Impurity 45 (CAS CATO-C4X-104445)
- Dexrazoxane Impurity 27 (CAS 120418-77-1)
- Pimobendan EP Impurity B (CAS CATO-C4X-246111)
- Regorafenib Impurity 36 (CAS 864245-61-4)
- (5-(3-(Trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-yl)methanamine (CAS 944906-90-5)
- (1R,5S,6S)-tert-Butyl 6-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate (CAS 2126144-35-0)
- Methyl 3-amino-4-(trifluoromethoxy)benzoate (CAS 721-09-5)
- 251316-97-9 Fmoc-Dap(Adpoc)-OH MFCD01318731 (CAS 251316-97-9)
- (S)-2,2'-((2-(2-Carboxypyrrolidin-1-yl)-2-oxoethyl)azanediyl)diacetic acid (CAS 93583-08-5)
- Insulin Degludec Impurity 5 (CAS CATO-C4X-21575)
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