Milnacipran Impurity 19 (And Enantiomer) CAS 105310-47-2
| CAS No. | 105310-47-2 |
| Molecular Formula | C15H22N2O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Milnacipran Impurity 19 (And Enantiomer) (C15H22N2OHCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Milnacipran Impurity 19 (And Enantiomer) (CAS 105310-47-2) is a certified pharmaceutical impurity reference standard with the molecular formula C15H22N2OHCl and a molecular weight of 282.81 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H22N2O HCl |
| Molecular Weight | 282.81 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Milnacipran Standards
- Milnacipran hydrochloride (CAS 101152-94-7)
- Milnacipran impound 35 (CAS 105310-24-5)
- Milnacipran Impurity 44 (CAS 105310-28-9)
- Milnacipran Impurity 43 (CAS 105310-47-2 (free base))
- Milnacipran Impurity N13 (CAS 105310-75-6)
- Milnacipran Impurity 40 (CAS 1100753-09-0)
- Milnacipran impurity 30 (CAS 115373-42-7)
- Milnacipran Carbamoyl-β-D-glucuronide Methyl Ester(Mixture of Diastereomers) (CAS 1191034-22-6)
Recommended Standards
- Rifapentine Impurity N1 (3-Formyl-Desacetyl Rifapentine) (CAS 16783-97-4)
- Ozagrel Impurity 28 (CAS 103549-17-3)
- Selexipag Impurity 21 (CAS CATO-C4X-196121)
- 5-bromo-1-tetrahydropyran-2-yl-pyrazolo[3,4-c]pyridine (CAS 1416713-71-7)
- 3-Hydroxy-4,5,7-trimethoxyflavanone (CAS 76792-94-4)
- 2,2-Diphenyl-mutyronitrile (CAS 5558-68-9)
- 2-Bromo-1,4-bis(((2-methoxypropan-2-yl)oxy)methyl)benzene (CAS 1019209-73-4)
- (5E)-3-Ethyl-5-{[4-(4-methylpiperazin-1-yl)-3-nitrophenyl]methylidene}-1,3-thiazolidine-2,4-dione (CAS 685109-11-9)
- 2-Tert-butylpropane-1,3-diol (CAS 2819-05-8)
- (D-His1)-Exenatide trifluoroacetate salt (CAS 1678417-09-8)
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