Rifapentine Impurity N1 (3-Formyl-Desacetyl Rifapentine) CAS 16783-97-4
| CAS No. | 16783-97-4 |
| Molecular Formula | C36H45NO12 |
| Molecular Weight | 683.74 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Rifapentine Impurity N1 (3-Formyl-Desacetyl Rifapentine) (CAS 16783-97-4, C36H45NO12) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Rifapentine Impurity N1 (3-Formyl-Desacetyl Rifapentine) is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 683.74 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C36H45NO12 |
| Molecular Weight | 683.74 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Nitrogen Atoms | 1 |
Related Rifapentine Standards
- Rifapentine impurity 20 (CAS CATO-C4X-195920)
- Rifapentine impurity 17 (CAS CATO-C4X-195917)
- Rifapentine Impurity 13 (CAS CATO-C4X-195913)
- Rifapentine Impurity 14 (CAS CATO-C4X-195914)
- Rifapentine impurity 22 (CAS 75922-14-4)
- Rifapentine impurity 24 (CAS CATO-C4X-195924)
- Rifapentine impurity 25 (CAS CATO-C4X-195925)
- Rifapentine Impurity 7 (CAS 27557-15-9)
Recommended Standards
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- Posaconazole Impurity 80 (CAS CATO-C4X-1208180)
- 3,3-Dimethyl-1,2,3,4,9,10-hexahydroacridine-1,9-dione (CAS 106220-39-7)
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- 2-(4-CHLORO-1H-INDOL-3-YL)ETHANAMINE HCL (CAS 2447-16-7)
- DAPK Substrate Peptide (CAS 386769-53-5)
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