Canagliflozin Impurity 10 CAS 1818268-45-9

Purity >95%In StockPharmacopoeial Impurity Standards
CAS No.1818268-45-9
Molecular FormulaC18H14FIOS
Molecular Weight424.27 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Canagliflozin Impurity 10 CAS 1818268-45-9 chemical structure

Description

The occurrence of Canagliflozin Impurity 10 is closely related to a steroid core, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine/iodine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

Canagliflozin Impurity 10 (CAS 1818268-45-9) is a certified pharmaceutical impurity reference standard with the molecular formula C18H14FIOS and a molecular weight of 424.27 g/mol.

Based on its molecular formula C18H14FIOS, Canagliflozin Impurity 10 contains a steroid core, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine/iodine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 424.27 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC18H14FIOS
Molecular Weight424.27 g/mol
Purity>95%
StorageStore at room temperature, protect from light
Solubility (reference)Soluble in chloroform, dichloromethane, ethyl acetate, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)11.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1995
Halogen ContentF/I-containing
Sulfur Atoms1

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