4,5-Dichloro-6-(chloromethyl)-pyrimidine CAS 105708-06-3

Purity 97%+In StockPharmaceutical Standards
CAS No.105708-06-3
Molecular FormulaC5H3Cl3N2
Molecular Weight197.45 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

4,5-Dichloro-6-(chloromethyl)-pyrimidine CAS 105708-06-3 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 197.45 g/mol gives 4,5-Dichloro-6-(chloromethyl)-pyrimidine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

4,5-Dichloro-6-(chloromethyl)-pyrimidine (CAS 105708-06-3), molecular formula C5H3Cl3N2 and molecular weight 197.45 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 4,5-Dichloro-6-(chloromethyl)-pyrimidine (C5H3Cl3N2) is characterized by a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 4,5-Dichloro-6-(chloromethyl)-pyrimidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC5H3Cl3N2
Molecular Weight197.45 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)4.0
UV AbsorptionUV-absorbing
CAS Registry Year (est.)1987
Halogen ContentCl-containing
Nitrogen Atoms2

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