Atrasentan Impurity 133 CAS 1058349-06-6
| CAS No. | 1058349-06-6 |
| Molecular Formula | C34H48N2O6 |
| Molecular Weight | 580.77 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Atrasentan Impurity 133 (CAS 1058349-06-6) is a certified pharmaceutical impurity reference standard with the molecular formula C34H48N2O6 and a molecular weight of 580.77 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Atrasentan Impurity 133 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 580.77 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C34H48N2O6 |
| Molecular Weight | 580.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 2 |
Related Atrasentan Standards
- Atrasentan Impurity 105 (CAS 1059052-12-8)
- Atrasentan Impurity 114 (CAS 1073746-06-1)
- Atrasentan Impurity 137 (CAS 1058349-12-4)
- Atrasentan Impurity 139 (CAS 1058349-18-0)
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