Diclofenac Impurity 21 CAS 105836-68-8
| CAS No. | 105836-68-8 |
| Molecular Formula | C12H9Cl2N |
| Molecular Weight | 238.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Diclofenac Impurity 21 (CAS 105836-68-8) is a certified pharmaceutical impurity reference standard with the molecular formula C12H9Cl2N and a molecular weight of 238.11 g/mol.
Based on its molecular formula C12H9Cl2N, Diclofenac Impurity 21 contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 238.11 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C12H9Cl2N |
| Molecular Weight | 238.11 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Diclofenac Standards
- Diclofenac Sodium Impurity 33 (CAS 58373-59-4)
- Diclofenac sodium Impurity 38 (CAS 15307-93-4)
- Diclofenac Related Compound 14 (CAS 3644-56-2)
- Diclofenac impurity 6 (CAS 860541-55-5)
- Diclofenac impurity 4 (CAS 1928-49-0)
- Diclofenac Impurity 41 (CAS 131023-45-5)
- Diclofenac sodium Impurity 6 (CAS 70172-33-7)
- Diclofenac Impurity N1 (CAS 131023-43-3)
Recommended Standards
- 42599-17-7 1(E)-Iodo-oct-1-ene MFCD12406808 (E)-1-Iodooct-1-ene/ trans-1-Iodo-1-octene (CAS 42599-17-7)
- Bis(4-chlorophenyl)amine (CAS 6962-04-5)
- 8-Iodooct-1-ene (CAS 38380-55-1)
- 4-Bromo-6-isopropyl-1H-indole (CAS 1000343-72-5)
- Capecitabine EP Impurity G (CAS 162204-20-8)
- Pioglitazone impurity 29 (CAS CATO-C4X-138329)
- Alogliptin Impurity 98 (CAS CATO-C4X-109998)
- 7-bromo-1-methyl-1H-pyrazolo[4,3-c]pyridine (CAS 1367795-99-0)
- (S)-N-((S)-2-hydroxy-1,2,2-triphenylethyl)pyrrolidine-2-carboxamide (CAS 910110-48-4)
- 7-Chloro-8-methyl-2-(3-propoxyphenyl)quinoline-4-carboxylic acid (CAS 863185-11-9)
- Pcb No. 159 (CAS 39635-35-3)
- 2-Butoxy-N-(2-(diethylamino)ethyl)-N-(2,6-dimethylphenyl)quinoline-4-carboxamide hydrochloride (CAS 77966-20-2)
- 2-Bromo-5-chloro-4-fluorophenacyl chloride (CAS 1805576-85-5)
- Cholecystokinin, CCK Tetrapeptide (30-33) (CAS 35144-91-3)
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