Diclofenac impurity 6 CAS 860541-55-5
| CAS No. | 860541-55-5 |
| Molecular Formula | C8H5Cl3O2 |
| Molecular Weight | 239.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Diclofenac impurity 6 (C8H5Cl3O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Diclofenac impurity 6 (CAS 860541-55-5) is a certified pharmaceutical impurity reference standard with the molecular formula C8H5Cl3O2 and a molecular weight of 239.48 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5Cl3O2 |
| Molecular Weight | 239.48 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
Related Diclofenac Standards
- Diclofenac Related Compound 14 (CAS 3644-56-2)
- Diclofenac Impurity 21 (CAS 105836-68-8)
- Diclofenac Sodium Impurity 33 (CAS 58373-59-4)
- Diclofenac sodium Impurity 38 (CAS 15307-93-4)
- Diclofenac Impurity 41 (CAS 131023-45-5)
- Diclofenac impurity 4 (CAS 1928-49-0)
- Diclofenac sodium Impurity 6 (CAS 70172-33-7)
- Diclofenac impurity 10 (CAS 172494-87-0)
Recommended Standards
- Methyl 2,4,5-trichlorobenzoate (CAS 86569-81-5)
- Topiramate Impurity 13 (CAS 86569-78-0)
- Chloromethyl 2,4-dichlorobenzoate (CAS 70190-72-6)
- Tranexamic Impurity 11 (CAS 5264-40-4)
- Apremilast Impurity 27 (CAS CATO-C4X-100927)
- Atogepant Impurity 90 (CAS CATO-C4X-328590)
- Pregabalin Impurity 140 (CAS CATO-C4X-1312140)
- 3-(2-Fluoro-4-iodophenoxy)azetidine hydrochloride (CAS 2431965-39-6)
- 3-Methyl-3-(piperidin-1-yl)indolin-2-one (CAS 55490-24-9)
- 2-(Allylthio)-3,5,6,7-tetrahydro-4H-cyclopenta[d]pyrimidin-4-one (CAS 905084-13-1)
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- 2-(1,3-benzothiazol-2-ylamino)acetohydrazide (CAS 325766-88-9)
- (2R)-4-(4-Fluorobenzyl)-2-methylpiperidine hydrochloride (CAS 1439922-25-4)
- Osteogenic Growth Peptide (10-14) (CAS 105250-85-9)
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