Diclofenac Sodium Impurity 33 CAS 58373-59-4
| CAS No. | 58373-59-4 |
| Molecular Formula | C12H9Cl2N |
| Molecular Weight | 238.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Diclofenac Sodium Impurity 33 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Diclofenac Sodium Impurity 33 (CAS 58373-59-4, C12H9Cl2N) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C12H9Cl2N, Diclofenac Sodium Impurity 33 contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 238.11 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C12H9Cl2N |
| Molecular Weight | 238.11 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Diclofenac Standards
- Diclofenac Impurity 21 (CAS 105836-68-8)
- Diclofenac sodium Impurity 38 (CAS 15307-93-4)
- Diclofenac Related Compound 14 (CAS 3644-56-2)
- Diclofenac impurity 6 (CAS 860541-55-5)
- Diclofenac impurity 4 (CAS 1928-49-0)
- Diclofenac Impurity 41 (CAS 131023-45-5)
- Diclofenac sodium Impurity 6 (CAS 70172-33-7)
- Diclofenac Impurity N1 (CAS 131023-43-3)
Recommended Standards
- 42599-17-7 1(E)-Iodo-oct-1-ene MFCD12406808 (E)-1-Iodooct-1-ene/ trans-1-Iodo-1-octene (CAS 42599-17-7)
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- Bis(4-chlorophenyl)amine (CAS 6962-04-5)
- 2-(4-bromo-3-methylphenyl)-2-methylpropanenitrile (CAS 1006390-25-5)
- N-Nitroso Dextromethorphan EP Impurity A (CAS CATO-C4X-115739)
- Ticagrelor Impurity 118 (CAS 2205903-72-4)
- Acetazolamide EP Impurity F(Triethylamine salt) (CAS 80495-47-2(Free Acid))
- N-(5-Amino-2-methoxyphenyl)-2-(4-isopropylphenoxy)acetamide (CAS 1020054-34-5)
- 22679-54-5 4-tert-Butylbenzophenone Methanone, (4-(1,1-dimethylethyl)phenyl)phenyl- EINECS 245-154-1 (CAS 22679-54-5)
- 4-Hydrazinyl-5-iodo-2,6-dimethylpyrimidine (CAS 454473-80-4)
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- Divinyl Adipate (CAS 4074-90-2)
- 3,3-Diethyl-1-(propylthio)cyclobutane-1-carboxylic acid (CAS 1488590-35-7)
- Met(O)14-Exenatide trifluoroacetate salt (CAS 1678417-38-3)
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