Atrasentan Impurity 83 CAS 1058552-28-5
| CAS No. | 1058552-28-5 |
| Molecular Formula | C33H46N2O7 |
| Molecular Weight | 582.74 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Atrasentan Impurity 83 (CAS 1058552-28-5, C33H46N2O7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Atrasentan Impurity 83 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 582.74 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C33H46N2O7 |
| Molecular Weight | 582.74 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 2 |
Related Atrasentan Standards
- Atrasentan Impurity 80 (CAS 1058552-22-9)
- Atrasentan Impurity 84 (CAS 1058552-29-6)
- Atrasentan Impurity 60 (CAS 1072963-94-0)
- Atrasentan Impurity 127 (CAS 1063835-98-2)
- Atrasentan Impurity 128 (CAS 1063835-95-9)
- Atrasentan Impurity 55 (CAS 1063836-03-2)
- Atrasentan Impurity 105 (CAS 1059052-12-8)
- Atrasentan Impurity 114 (CAS 1073746-06-1)
Recommended Standards
- 9,10-Di(naphthalen-2-yl)-2,6-diphenylanthracene (CAS 660427-97-4)
- Gal[246Bn,3All]-β-SPh (CAS 1017587-57-3)
- 9,10-Bis(4-phenylnaphthalen-1-yl)anthracene (CAS 722498-65-9)
- 9,10-Bis(4-(naphthalen-2-yl)phenyl)anthracene (CAS 377738-12-0)
- Pitavastatin Impurity 124 (CAS 1422058-52-3)
- Warfarin impurity 13 (CAS CATO-C4X-17813)
- Fenfluramine Impurity 1 (CAS 52777-74-9)
- 1-tert-Butyl 2-ethyl (2S,4S)-4-hydroxypiperidine-1,2-dicarboxylate (CAS 180854-46-0)
- 1-(4h-1,2,4-Triazol-4-yl)propan-2-amine (CAS 1341337-53-8)
- 3-((4-Bromobenzyl)oxy)pyrido[1,2-a]indole-10-carbonitrile (CAS 338981-96-7)
- tert-butyl 3-[[4-(2-hydroxy-2-methyl-propyl)piperazin-1-yl]methyl]-8-azabicyclo[3.2.1]octane-8-carboxylate (CAS 2308104-66-5)
- Loratadine Impurity 53 (CAS CATO-C4X-142653)
- Atorvastatin Impurity N6 (CAS 807312-27-2)
- (Pro30,Tyr32,Leu34)-Neuropeptide Y (28-36) (CAS 161650-01-7)
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