Atrasentan Impurity 60 CAS 1072963-94-0
| CAS No. | 1072963-94-0 |
| Molecular Formula | C33H48N3O6 |
| Molecular Weight | 582.75 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Atrasentan Impurity 60.
As a process- or degradation-related impurity, Atrasentan Impurity 60 (CAS 1072963-94-0, C33H48N3O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Atrasentan Impurity 60 (C33H48N3O6) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Atrasentan Impurity 60 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C33H48N3O6 |
| Molecular Weight | 582.75 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 3 |
Related Atrasentan Standards
- Atrasentan Impurity 80 (CAS 1058552-22-9)
- Atrasentan Impurity 83 (CAS 1058552-28-5)
- Atrasentan Impurity 84 (CAS 1058552-29-6)
- Atrasentan Impurity 127 (CAS 1063835-98-2)
- Atrasentan Impurity 128 (CAS 1063835-95-9)
- Atrasentan Impurity 55 (CAS 1063836-03-2)
- Atrasentan Impurity 105 (CAS 1059052-12-8)
- Atrasentan Impurity 114 (CAS 1073746-06-1)
Recommended Standards
- Gal[246Bn,3All]-β-SPh (CAS 1017587-57-3)
- N-(23-Azido-3,6,9,12,15,18,21-heptaoxatricosyl)-5-(1,2-dithiolan-3-yl)pentanamide (CAS 1350841-32-5)
- Cyclobutenediylium, 1-[(5-carboxy-1,3-dihydro-3,3-dimethyl-1-octyl-2H-indol-2-ylidene)methyl]-3-[(1-ethyl-1,3-dihydro-3,3-dimethyl-2H-indol-2-ylidene)methyl]-2,4-dihydroxy-, bis(inner salt) (CAS 951248-19-4)
- Butyl ((3-(4-((2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)methyl)phenyl)-5-isobutylthiophen-2-yl)sulfonyl)carbamate (CAS 151488-11-8)
- Iguratimod Impurity 151 (CAS 500887-53-6)
- Terbutaline Impurity 60 (CAS 35086-59-0)
- Indacaterol Impurity 6 (CAS 93609-84-8)
- 1-(4-Chlorobutyl)cyclobutane-1-carbonitrile (CAS 2137823-49-3)
- L-Selenomethionine (CAS 3211-76-5)
- Ethyl 2-(2-((5-amino-1H-1,2,4-triazol-3-yl)thio)acetamido)-4,5-dimethylthiophene-3-carboxylate (CAS 671200-17-2)
- 5220-39-3 11H-Cyclohepta(b)quinolin-11-one, 5,6,7,8,9,10-hexahydro- 5-21-08-00522 (Beilstein Handbook Reference) BRN 1529222 5,6,7,8,9,10-Hexahydro-11H-cyclohepta(b)quinolin-11-one 7,8,9,10-Tetrahydro-6H-cyclohepta(b)quinolin-11-one (CAS 5220-39-3)
- 5,8-Dihydro-5,8-methanonaphtho[2,3-d]-1,3-dioxole (CAS 94706-16-8)
- Moxifloxacin Impurity 193 (CAS CATO-C4X-1074193)
- Semaglutide impurity 214 (CAS CATO-C4X-2226214)
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