Erlotinib impurity 136 CAS 1058651-74-3
| CAS No. | 1058651-74-3 |
| Molecular Formula | C22H21N3O5 |
| Molecular Weight | 407.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 407.42 g/mol gives Erlotinib impurity 136 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Erlotinib impurity 136 (CAS 1058651-74-3, C22H21N3O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Erlotinib impurity 136 (C22H21N3O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Erlotinib impurity 136 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H21N3O5 |
| Molecular Weight | 407.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 3 |
Related Erlotinib Standards
- 4-Methyl Erlotinib (CAS 1346601-52-2)
- Erlotinib impurity 138 (CAS 1318600-03-1)
- Erlotinib Impurity 6 (CAS 882420-22-6)
- Erlotinib Impurity 91 (CAS 1354727-63-1)
- Erlotinib Impurity 3 (CAS 183321-82-6)
- Erlotinib Impurity 15 (CAS CATO-C4X-106915)
- Erlotinib Impurity 2 (CAS 183321-85-9)
- Erlotinib Impurity 103 (CAS 299912-61-1)
Recommended Standards
- Tankyrase-IN-3 (CAS 938893-79-9)
- Linezolid impurity 105 (CAS 556801-12-8)
- N-(Furan-2-ylmethyl)-2-imino-1-(2-methoxyethyl)-10-methyl-5-oxo-2,5-dihydro-1H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide (CAS 510762-40-0)
- Tadalafil Impurity 171 (CAS CATO-C4X-1087171)
- Flupentixol Impurity N15 (CAS 53772-82-0)
- Tibolone impurity 1 (CAS 100239-44-9)
- Prucalopride Impurity 13 (CAS 137211-64-4)
- 1-(Tert-butoxycarbonyl)-4-oxopiperidine-3-carboxylic acid (CAS 885274-97-5)
- 2-Phenyl-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one (CAS 74411-91-9)
- H-β-Cyclopropyl-Ala-OH (CAS 102735-53-5)
- Cis-2,3-dichloro-2,3-dihydrobenzofuran (CAS 63361-58-0)
- [(4-Methanesulfonylphenyl)methyl](methyl)amine (CAS 709649-56-9)
- Ethyl (2E,4E)-5-(pyridin-3-yl)penta-2,4-dienoate (CAS 78775-01-6)
- Mast Cell Degranulating Peptide (CAS 83856-13-7)
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