Erlotinib Impurity 3 CAS 183321-82-6
| CAS No. | 183321-82-6 |
| Molecular Formula | C20H17Cl2N3O2 |
| Molecular Weight | 402.27 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Erlotinib Impurity 3 (CAS 183321-82-6, C20H17Cl2N3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Erlotinib Impurity 3 (C20H17Cl2N3O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H17Cl2N3O2 |
| Molecular Weight | 402.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2009 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Erlotinib Standards
- Erlotinib Impurity 2 (CAS 183321-85-9)
- Erlotinib Impurity 103 (CAS 299912-61-1)
- Erlotinib D4 (CAS 1130852-41-3)
- Erlotinib impurity 136 (CAS 1058651-74-3)
- 4-Methyl Erlotinib (CAS 1346601-52-2)
- Erlotinib Impurity 93 (CAS 1058132-82-3)
- Erlotinib impurity 138 (CAS 1318600-03-1)
- Erlotinib Impurity 6 (CAS 882420-22-6)
Recommended Standards
- Tert-butyl 4-(3-iodobenzyl)piperazine-1-carboxylate (CAS 850375-09-6)
- Phloroglucinol impurity 60 (CAS CATO-C4X-221760)
- N-(5-(benzyloxy)-2,4-dichlorophenyl)-4-methoxybenzamide (CAS 338961-22-1)
- Gefapixant Impurity 3 (CAS CATO-C4X-28493)
- Rasagiline Impurity 40 (CAS CATO-C4X-191340)
- Mirabegron Impurity 73 (CAS 100-12-9)
- Brexpiprazole impurity 128 (CAS 2400917-55-5)
- 3-Hydroxy-3-(tetrahydrofuran-2-yl)acrylonitrile (CAS 1221820-97-8)
- 4707-32-8 6N4FA2QQ6A beta-Lapachone 2H-Naphtho(1,2-b)pyran-5,6-dione, 3,4-dihydro-2,2-dimethyl- 5-17-11-00459 (Beilstein Handbook Reference) BRN 0181499 3,4-Dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione Lapachone, beta- NSC 26326 NSC 629749 SL 11001 UNII-6N4FA2QQ6A ARQ 501 (CAS 4707-32-8)
- 1-(Cyclohexylamino)-4-((4-ethoxyphenyl)amino)anthracene-9,10-dione (CAS 77946-99-7)
- 2-Chloro-3-fluoro-4-nitropyridine 1-oxide (CAS 101664-56-6)
- 1-(5-Nitrothiazol-2-yl)pyrrolidin-2-one (CAS 13109-99-4)
- 6-Isobutoxy-5-methylpyridin-3-amine (CAS 1249789-40-9)
- Semaglutide Impurity 158 (x TFA Salt) (CAS CATO-C4X-2226158)
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