Erythromycin EP Impurity J CAS 105900-46-7
| CAS No. | 105900-46-7 |
| Molecular Formula | C37H67NO13 |
| Molecular Weight | 733.93 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 733.93 g/mol gives Erythromycin EP Impurity J distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Erythromycin EP Impurity J (CAS 105900-46-7, C37H67NO13) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Erythromycin EP Impurity J is typically off-white to pale yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 733.93 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C37H67NO13 |
| Molecular Weight | 733.93 g/mol |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 1 |
Related Erythromycin Standards
- Erythromycin (CAS 114-07-8)
- Erythromycin EP Impurity M (CAS 616234-56-1)
- Erythromycin Impurity 23 (CAS 226086-79-9)
- Erythromycin Sulfonamide Impurity B Oxime Derivative (CAS 231620-64-7)
- Erythromycin-N,N-dimethyl-13C2 A (CAS 202114-52-1)
- Erythromycin A 6,9-Iminoether (CAS CATO-C4X-100128)
- Erythromycin A 9,11-Iminoether (CAS CATO-C4X-100131)
- Erythromycin impurity 58 (CAS 145259-56-9)
Recommended Standards
- HO-Ste-D-γGlu-AEEA-AEEA-OH (CAS CATO-C4X-2226284)
- Clarithromycin EP Impurity B (CAS 299409-85-1)
- Semaglutide Impurity 21(HO-Ste-L-γGlu-AEEA-AEEA-OH) (CAS 1335440-44-2)
- Clarithromycin EP Impurity D (CAS 101666-68-6)
- Dexmedetomidine Impurity 36 (CAS 86347-14-0)
- Fruquintinib Impurity 16 (CAS CATO-C4X-303716)
- Lacosamide Impurity 54 (CAS CATO-C4X-183054)
- Lumefantrine Impurity N1 (CAS 2170653-95-7 (free base))
- 6-methoxy-alpha-(methyl-d3)-2-naphthaleneaceticacid (CAS 958293-77-1)
- 2-(5-Ethoxy-1,6-dimethyl-2,4-dioxo-1,4-dihydropyrido[2,3-d]pyrimidin-3(2H)-yl)-N-methylacetamide (CAS 941946-99-2)
- 4-{[(4-chlorophenyl)methyl]sulfanyl}-11,13-dimethyl-N-(propan-2-yl)-8-thia-3,5,10-triazatricyclo[7.4.0.0^{2,7}]trideca-1(13),2(7),3,5,9,11-hexaen-6-amine (CAS 478065-75-7)
- 7-Methyl-2,4-dioxo-1,2,3,4-tetrahydrobenzo[g]pteridine-8-carboxylic acid (CAS 84869-39-6)
- 2-(5-(M-tolyl)-2H-tetrazol-2-yl)acetic acid (CAS 81595-01-9)
- Semaglutide impurity 215 (CAS CATO-C4X-2226215)
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