Adapalene Impurity 12 CAS 1063712-23-1
| CAS No. | 1063712-23-1 |
| Molecular Formula | C28H28O3 |
| Molecular Weight | 412.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Adapalene Impurity 12 (CAS 1063712-23-1, C28H28O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C28H28O3, Adapalene Impurity 12 contains a steroid core, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 412.52 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C28H28O3 |
| Molecular Weight | 412.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
Related Adapalene Standards
- Adapalene Impurity 13 (CAS 106685-43-2)
- Adapalene (CAS 106685-40-9)
- Adapalene-d6 (CAS CATO-C4X-180918)
- Adapalene Impurity 5 (CAS 106685-41-0)
- Adapalene EP Impurity B (CAS 1346599-76-5)
- Adapalene Impurity 10 (CAS 161912-38-5)
- Adapalene Impurity 16 (CAS CATO-C4X-180916)
- Adapalene Impurity 14 (CAS 1036766-56-9)
Recommended Standards
- Cyproterone Acetate EP Impurity B (CAS CATO-C4X-16013)
- Dapoxetine Impurity 91 (CAS CATO-C4X-143991)
- Thiotepa Impurity 9 (CAS CATO-C4X-21569)
- Dapoxetine Impurity 81 (CAS 2415108-74-4)
- Amoxicillin EP impurity B (CAS 26889-93-0)
- Amoxicillin Impurity 36 (CAS CATO-C4X-114836)
- Irbesartan Impurity 45 (CAS CATO-C4X-166645)
- [4,4'-Bipyrimidine]-2,2',6(1H,3H,3'H)-trione (CAS 35612-19-2)
- 2-(sec-Butyl)aniline (CAS 55751-54-7)
- Decane-4,7-dione (CAS 22633-21-2)
- 2-Phenyl-2-(trimethylsilyl)ethanol (CAS 122760-31-0)
- Sodium 3-((4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazin-2-yl)amino)benzenesulfonate (CAS 25807-84-5)
- n-(4-Formyl-2-pyridyl)acetamide (CAS 149141-10-6)
- Liraglutide Impurity 17 TFA Salt (CAS CATO-C4X-199217)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com