Adapalene Impurity 10 CAS 161912-38-5
| CAS No. | 161912-38-5 |
| Molecular Formula | C24H18O4 |
| Molecular Weight | 370.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Adapalene Impurity 10 (CAS 161912-38-5) is a certified pharmaceutical impurity reference standard with the molecular formula C24H18O4 and a molecular weight of 370.40 g/mol.
The molecular framework of Adapalene Impurity 10 (C24H18O4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H18O4 |
| Molecular Weight | 370.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
Related Adapalene Standards
- Adapalene Impurity 14 (CAS 1036766-56-9)
- Adapalene Impurity 11 (CAS CATO-C4X-180911)
- Adapalene EP Impurity A (CAS 932033-58-4)
- Adapalene Impurity 12 (CAS 1063712-23-1)
- Adapalene Impurity 13 (CAS 106685-43-2)
- Adapalene (CAS 106685-40-9)
- Adapalene-d6 (CAS CATO-C4X-180918)
- Adapalene impurity 20 (CAS CATO-C4X-180920)
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