Doxorubicin Impurity N19 CAS 106401-68-7
| CAS No. | 106401-68-7 |
| Molecular Formula | C29H34BrNO11 |
| Molecular Weight | 652.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Doxorubicin Impurity N19 (CAS 106401-68-7) is a certified pharmaceutical impurity reference standard with the molecular formula C29H34BrNO11 and a molecular weight of 652.48 g/mol.
Structurally, Doxorubicin Impurity N19 (C29H34BrNO11) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 652.48 g/mol, it falls into the high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Doxorubicin Impurity N19 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C29H34BrNO11 |
| Molecular Weight | 652.48 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Doxorubicin Standards
- Doxorubicin Impurity 27 (CAS CATO-C4X-203327)
- Doxorubicin Impurity 25 (CAS CATO-C4X-203325)
- Doxorubicin Impurity 28 (CAS CATO-C4X-203328)
- Doxorubicin-hydrazone-caproyl-maleimide (CAS 151038-96-9)
- Doxorubicin Impurity 33 (CAS CATO-C4X-203333)
- Doxorubicin Impurity 9 (CAS CATO-C4X-20339)
- Doxorubicin (CAS 23214-92-8)
- Doxorubicin Impurity 20 (CAS CATO-C4X-203320)
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