Doxorubicin Impurity 25 CAS CATO-C4X-203325
| CAS No. | CATO-C4X-203325 |
| Molecular Formula | C27H27Cl2NO10 |
| Molecular Weight | 596.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Doxorubicin Impurity 25 (CAS CATO-C4X-203325, C27H27Cl2NO10) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C27H27Cl2NO10, Doxorubicin Impurity 25 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 596.41 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Doxorubicin Impurity 25 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C27H27Cl2NO10 |
| Molecular Weight | 596.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Doxorubicin Standards
- Doxorubicin Impurity 28 (CAS CATO-C4X-203328)
- Doxorubicin Impurity 33 (CAS CATO-C4X-203333)
- Doxorubicin Impurity 9 (CAS CATO-C4X-20339)
- Doxorubicin (CAS 23214-92-8)
- Doxorubicin Impurity 20 (CAS CATO-C4X-203320)
- Doxorubicin Impurity 29 (CAS CATO-C4X-203329)
- Doxorubicin Impurity N19 (CAS 106401-68-7)
- Doxorubicin Impurity 3 (CAS 69429-21-6)
Recommended Standards
- CAS 2342615-74-9 (CAS 2342615-74-9)
- (E)-3-(4-((2,4-Bis(trifluoromethyl)benzyl)oxy)-3-methoxyphenyl)-2-cyano-N-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)acrylamide (CAS 796844-24-1)
- 3,5,7,9,10-Pentachloro-2,2,3,4,4,5,6,6,7,8,8,9,10,10-tetradecafluorodecanoic acid (CAS 335-74-0)
- 3-[4-[[2,4-Bis(trifluoromethyl)benzyl]oxy]-3-methoxyphenyl]-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acrylamide (CAS 725247-18-7)
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