Ethyl 5-chloro-4-hydroxy-8-(trifluoromethyl)quinoline-3-carboxylate CAS 1065102-35-3
| CAS No. | 1065102-35-3 |
| Molecular Formula | C13H9ClF3NO3 |
| Molecular Weight | 319.66 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Ethyl 5-chloro-4-hydroxy-8-(trifluoromethyl)quinoline-3-carboxylate (CAS 1065102-35-3), molecular formula C13H9ClF3NO3 and molecular weight 319.66 g/mol, is a CATO reference standard with documented purity and traceability.
Ethyl 5-chloro-4-hydroxy-8-(trifluoromethyl)quinoline-3-carboxylate (C13H9ClF3NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H9ClF3NO3 |
| Molecular Weight | 319.66 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Ethyl Standards
- Ethyl 4-chloro-8-(trifluoromethoxy)quinoline-3-carboxylate (CAS 1040013-63-5)
- Ethyl 8-chloro-4-hydroxy-6-(trifluoromethyl)quinoline-3-carboxylate (CAS 1065094-20-3)
- Ethyl 6-chloro-4-hydroxy-8-(trifluoromethyl)quinoline-3-carboxylate (CAS 1065102-34-2)
- Ethyl 8-chloro-4-hydroxy-5-(trifluoromethyl)quinoline-3-carboxylate (CAS 1221573-17-6)
- Methyl 4-chloro-6-methoxy-2-(trifluoromethyl)quinoline-3-carboxylate (CAS 1384264-19-0)
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- Ethyl 6-chloro-4-hydroxy-7-(trifluoromethyl)quinoline-3-carboxylate (CAS 958332-77-9)
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