Ethyl 3-(4-Chlorophenyl)-5-(trifluoromethyl)isoxazole-4-carboxylate CAS 1159978-85-4
| CAS No. | 1159978-85-4 |
| Molecular Formula | C13H9ClF3NO3 |
| Molecular Weight | 319.66 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ethyl 3-(4-Chlorophenyl)-5-(trifluoromethyl)isoxazole-4-carboxylate.
CATO supplies Ethyl 3-(4-Chlorophenyl)-5-(trifluoromethyl)isoxazole-4-carboxylate (CAS 1159978-85-4), a certified reference material (molecular formula C13H9ClF3NO3, MW 319.66 g/mol) for analytical method development and quality control.
The molecular framework of Ethyl 3-(4-Chlorophenyl)-5-(trifluoromethyl)isoxazole-4-carboxylate (C13H9ClF3NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Ethyl 3-(4-Chlorophenyl)-5-(trifluoromethyl)isoxazole-4-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H9ClF3NO3 |
| Molecular Weight | 319.66 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Ethyl Standards
- Ethyl 2-(2-chlorophenyl)-5-(trifluoromethyl)-2H-1,2,3-triazole-4-carboxylate (CAS 1431729-86-0)
- 3-(4-Chlorophenyl)sulfanyl-1-methyl-5-(trifluoromethyl)pyridin-2-one (CAS 1924322-42-8)
- 4-[(2-Chlorophenyl)sulfanyl]-N-methyl-6-(trifluoromethyl)pyrimidin-2-amine (CAS 400086-86-4)
- 1-(4-Chlorophenyl)-3-(2-(2-nitroethyl)phenyl)urea (CAS 338410-35-8)
- Methyl 2-(3-(5-(2-chlorophenyl)furan-2-yl)acrylamido)acetate (CAS 853356-06-6)
- N-(2-Chlorophenyl)-2-(4-formyl-2-methoxyphenoxy)acetamide (CAS 247592-73-0)
- 2-[(2-chlorophenyl)formamido]-4-methanesulfonylbutanoic acid (CAS 1025058-89-2)
- (2E)-1-[(4-Chlorophenyl)sulfanyl]-3-(3-nitrophenyl)prop-2-en-1-one (CAS 331462-27-2)
Recommended Standards
- Ethyl 5-chloro-4-hydroxy-8-(trifluoromethyl)quinoline-3-carboxylate (CAS 1065102-35-3)
- Ethyl 8-chloro-4-hydroxy-5-(trifluoromethyl)quinoline-3-carboxylate (CAS 1221573-17-6)
- Ethyl 6-chloro-4-hydroxy-8-(trifluoromethyl)quinoline-3-carboxylate (CAS 1065102-34-2)
- Methyl 4-chloro-6-methoxy-2-(trifluoromethyl)quinoline-3-carboxylate (CAS 1384264-19-0)
- 3-(4-chloro-3-fluorophenoxy)propanoic acid (CAS 1499920-96-5)
- 9-methylnonadecane (CAS 13287-24-6)
- 6-(Difluoromethyl)pyrimidin-4(3H)-one (CAS 126538-89-4)
- NG, N'G-Dimethyl-L-arginine di(p-hydroxyazobenzene-p'-sulfonate) (CAS 102783-24-4)
- EIcosanamide (CAS 51360-63-5)
- 1-(6,7-Difluorobenzofuran-2-yl)butan-1-one (CAS 1488705-99-2)
- Cyclododecane-1,4-dione (CAS 27567-77-7)
- 5-(4-Methoxy-benzyl)-[1,3,4]thiadiazol-2-ylamine (CAS 63617-18-5)
- 4-(Dimethylamino)-3-isopropoxyphenol (CAS 855409-95-9)
- D-Glu3-Tirzepatide (CAS CATO-CPTD788927)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com