8-Trifluoromethoxyquinoline-5-boronic acid CAS 1072951-46-2
| CAS No. | 1072951-46-2 |
| Molecular Formula | C10H7BF3NO3 |
| Molecular Weight | 256.97 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 8-Trifluoromethoxyquinoline-5-boronic acid is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
8-Trifluoromethoxyquinoline-5-boronic acid (CAS 1072951-46-2) is a high-purity analytical reference standard with the molecular formula C10H7BF3NO3 and a molecular weight of 256.97 g/mol.
The molecular framework of 8-Trifluoromethoxyquinoline-5-boronic acid (C10H7BF3NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 8-Trifluoromethoxyquinoline-5-boronic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H7BF3NO3 |
| Molecular Weight | 256.97 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- 5-Bromo-4-(bromomethyl)thiazole (CAS 240433-75-4)
- [6-(Trifluoromethoxy)quinolin-8-yl]boronic acid (CAS 1089179-11-2)
- 5-Bromo-3-(bromomethyl)isothiazole (CAS 4576-94-7)
- 2,5-DIBROMOBENZENAMINE 2,5-Dibromoaniline 3638-73-1 AS00471 ATTERCOP-CHM AT130477 OTAVA-BB 1506319 RARECHEM FH 1W 0043 (CAS 3638-73-1)
- Quinoline-5,8-disulfonic acid (CAS 5825-30-9)
- 4-Amino-4-(2-chlorophenyl)tetrahydro-2h-thiopyran 1,1-dioxide hydrochloride (CAS 2490698-36-5)
- 5-Chloro-8-nitroquinoline (CAS 6942-98-9)
- (2-oxo-ethyl)-carbamic acid tert-butyl ester 89711-08-0 N-Boc-2-aminoacetaldehyde boc-l-glycinal t-butyl n-(2-oxoethyl)cabamate (CAS 89711-08-0)
- 1-(2-Chlorophenyl)-3-phenylpropan-1-one (CAS 898764-45-9)
- 2-(3-Bromo-5-fluorophenyl)ethylamine (CAS 910386-92-4)
- Cephaloglycin (CAS 3577-01-3)
- N-(2-Chlorophenyl)pivalamide (CAS 62662-74-2)
- Vazegepant Impurity 8 (CAS CATO-C4X-32008)
- Tau Peptide (295-309) trifluoroacetate salt (CAS 330456-46-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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