Atrasentan Impurity 181 CAS 1073590-82-5
| CAS No. | 1073590-82-5 |
| Molecular Formula | C33H46N2O6 |
| Molecular Weight | 566.74 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Atrasentan Impurity 181.
Atrasentan Impurity 181 (CAS 1073590-82-5) is a certified pharmaceutical impurity reference standard with the molecular formula C33H46N2O6 and a molecular weight of 566.74 g/mol.
Atrasentan Impurity 181 (C33H46N2O6) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Atrasentan Impurity 181 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C33H46N2O6 |
| Molecular Weight | 566.74 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 2 |
Related Atrasentan Standards
- Atrasentan Impurity 101 (CAS 1059052-04-8)
- Atrasentan Impurity 112 (CAS 1059754-98-1)
- Atrasentan Impurity 140 (CAS 1058349-19-1)
- Atrasentan Impurity 152 (CAS 1058404-01-5)
- Atrasentan Impurity 154 (CAS 1058404-07-1)
- Atrasentan Impurity 168 (CAS 1059043-43-4)
- Atrasentan Impurity 169 (CAS 1059043-50-3)
- Atrasentan Impurity 173 (CAS 1059051-91-0)
Recommended Standards
- Atrasentan Impurity 175 (CAS 1059051-98-7)
- 3,6,9,12,15,18,21,24-Octaoxaheptatriacontanoic acid (CAS 66161-61-3)
- Atrasentan Impurity 174 (CAS 1059051-97-6)
- 4,4'-Bis(2,2-di-p-tolylvinyl)-1,1'-biphenyl (CAS 135804-06-7)
- Semaglutide impurity 29 (CAS CATO-C4X-222629)
- Celecoxib Impurity 9 (CAS 1061214-06-9)
- Flomoxef Impurity 46 (CAS CATO-C4X-138246)
- 6-[(3-Aminophenyl)methyl]-4,6-dihydro-4-methyl-2-(methylsulfinyl)-5H-thieno[2,3:4,5]pyrrolo[2,3-d]pyridazin-5-one (CAS 1221186-53-3)
- Methyl 9-(hydroxymethyl)-9H-purine-6-carboxylate (CAS 95121-26-9)
- 5-Methoxy-2-thiophenemethanamine (CAS 1061651-71-5)
- N-(4-(1H-Indol-3-yl)thiazol-2-yl)acetamide (CAS 189011-09-4)
- Ciramadol (CAS 63269-31-8)
- 1-(2-Ethoxyethyl)-1h-indol-4-amine (CAS 1485657-11-1)
- Valosin Peptide (VQY), porcine (CAS 99510-37-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com