Apixaban Impurity 27 CAS 1074549-89-5
| CAS No. | 1074549-89-5 |
| Molecular Formula | C25H23N5O4 |
| Molecular Weight | 457.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, Apixaban Impurity 27 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 457.48 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Apixaban Impurity 27 (CAS 1074549-89-5) is a certified pharmaceutical impurity reference standard with the molecular formula C25H23N5O4 and a molecular weight of 457.48 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Apixaban Impurity 27 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H23N5O4 |
| Molecular Weight | 457.48 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 5 |
Related Apixaban Standards
- Apixaban 4,5-Dehydro Carboxylic Acid (CAS 2518444-61-4)
- Apixaban (CAS 503612-47-3)
- Apixaban Impurity 124 (CAS 1801881-18-4)
- Apixaban Impurity 126 (CAS 1801881-16-2)
- Apixaban Impurity 72 (CAS CATO-C4X-108872)
- Apixaban Impurity 1 (CAS 503614-92-4)
- Apixaban-d3 (CAS 1131996-12-7)
- Apixaban Impurity 108 (CAS CATO-C4X-1088108)
Recommended Standards
- Mitoxantrone Impurity 22 (CAS CATO-C4X-103422)
- Cefoxitin EP Impurity E (CAS 2395025-32-6)
- Mitoxantrone Impurity 19 (CAS CATO-C4X-103419)
- Cefoxitin EP Impurity F (CAS 2395025-37-1)
- Ensifentrine impurity 45 (CAS 3088358-10-2)
- Sotagliflozin Impurity 3 (CAS CATO-C4X-30043)
- Ertapenem Impurity 32 (CAS 1199797-42-6)
- N-acetyl-N-(4-bromophenyl)acetamide (CAS 78560-01-7)
- 2-(5-amino-1,3,4-thiadiazol-2-yl)propan-2-ol (CAS 933911-74-1)
- 2-(5-Amino-[1,3,4]thiadiazol-2-yl)-N-(4-methoxy-phenyl)-acetamide (CAS 878656-32-7)
- 3-Methyl-5,6,7,8-tetrahydroquinolin-5-amine (CAS 790604-10-3)
- 3-(4-Fluorophenyl)-6-(trifluoromethyl)picolinic acid (CAS 1214379-14-2)
- N-(2-Ethoxyphenyl)-2-((3-ethyl-5,6-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetamide (CAS 618427-64-8)
- β-Asp9-Tirzepatide (CAS CATO-CPTD788931)
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