Ciclosporin EP Impurity D CAS 108027-45-8
| CAS No. | 108027-45-8 |
| Molecular Formula | C61H109N11O12 |
| Molecular Weight | 1188.58 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Ciclosporin EP Impurity D (CAS 108027-45-8), a pharmacopoeial impurity reference standard (molecular formula C61H109N11O12, MW 1188.58 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C61H109N11O12, Ciclosporin EP Impurity D contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 1188.58 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C61H109N11O12 |
| Molecular Weight | 1188.58 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 11 |
Related Ciclosporin Standards
- Ciclosporin EP Impurity F (CAS 437611-17-1)
- Ciclosporin Impurity 19 (CAS CATO-C4X-199819)
- Ciclosporin Impurity 20 (CAS CATO-C4X-199820)
- Ciclosporin EP Impurity C (CAS 59865-16-6)
- Ciclosporin Impurity 12 (CAS CATO-C4X-199812)
- Ciclosporin Impurity 23 (CAS CATO-C4X-199823)
- Ciclosporin EP Impurity B (CAS 59865-15-5)
- Ciclosporin Impurity 11 (CAS CATO-C4X-199811)
Recommended Standards
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- Cyclosporin B (CAS 63775-95-1)
- Triclabendazole Impurity 5 (CAS 106791-37-1)
- Donepezil Impurity 58 (CAS 130927-68-3)
- Spiramycin EP Impurity H (CAS CATO-C1896290)
- 2-(5-Chloro-2-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (CAS 635305-39-4)
- Bosentan Impurity 21 (CAS CATO-C4X-156421)
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- 2-((4-Fluorophenyl)amino)-2-(thiophen-2-yl)acetic acid (CAS 725253-20-3)
- 3-(2,3-Dihydro-1h-isoindol-2-yl)propanoic acid hydrochloride (CAS 1255718-22-9)
- Hexapeptide-11 (CAS 100684-36-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com