Cyclosporin V (Ciclosporin EP Impurity E) CAS 108027-46-9
| CAS No. | 108027-46-9 |
| Molecular Formula | C63H113N11O12 |
| Molecular Weight | 1216.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 1216.64 g/mol gives Cyclosporin V (Ciclosporin EP Impurity E) distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Cyclosporin V (Ciclosporin EP Impurity E) (CAS 108027-46-9) is a certified pharmaceutical impurity reference standard with the molecular formula C63H113N11O12 and a molecular weight of 1216.64 g/mol.
The molecular framework of Cyclosporin V (Ciclosporin EP Impurity E) (C63H113N11O12) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Cyclosporin V (Ciclosporin EP Impurity E) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C63H113N11O12 |
| Molecular Weight | 1216.64 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Nitrogen Atoms | 11 |
Related Cyclosporin Standards
- Cyclosporin G (CAS 74436-00-3)
- Cyclosporin AM 9 (CAS 89270-25-7)
- Cyclosporin Impurity 12 (CAS 89270-28-0)
- Cyclosporin C (CAS 59787-61-0)
- Cyclosporin A-13C2,d4(Major) (CAS CATO-CCAD302963)
- Cyclosporin A-d4 (Major) (CAS CATO-C4X-13119)
- Cyclosporin A-d4 (Major) (CAS CATO-CCAD303641)
- Cyclosporin Impurity 16（Dihydrocyclosporin H） (CAS 83602-88-4)
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