Donepezil Impurity 58 CAS 130927-68-3
| CAS No. | 130927-68-3 |
| Molecular Formula | C24H29NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Donepezil Impurity 58 (C24H29NO2HCl) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO supplies Donepezil Impurity 58 (CAS 130927-68-3), a pharmacopoeial impurity reference standard (molecular formula C24H29NO2HCl, MW 399.96 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Donepezil Impurity 58 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H29NO2 HCl |
| Molecular Weight | 399.96 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Donepezil Standards
- Donepezil Impurity 15 (CAS 1023500-88-0)
- Donepezil Impurity 44 (CAS 1026443-48-0)
- Donepezil Impurity 46 (CAS 1034439-43-4)
- Donepezil-d5 (CAS 1128086-25-8)
- Donepezil Impurity 55 (CAS 1189443-74-0 (free base))
- Donepezil Related Compound A HCl (CAS 120011-69-0)
- Donepezil Hydrochloride (CAS 120011-70-3)
- Donepezil Impurity 25 (CAS 120012-04-6)
Recommended Standards
- Remdesivir Impurity 36 (CAS CATO-C4X-210036)
- Acotiamide Impurity 9 (CAS 948053-83-6)
- Ilaprazole impurity 189 (CAS CATO-C4X-1130189)
- Methyl 4-bromo-2-fluoro-6-nitrobenzoate (CAS 1805549-52-3)
- N-(3-aminopropyl)-2-bromobenzene-1-sulfonamide hydrochloride (CAS 1568624-53-2)
- Nafamostat Impurity 14 (CAS 62529-01-5)
- 1-(3-Bromo-4-methoxyphenyl)cyclopropan-1-ol (CAS 1242314-65-3)
- 5,6,7-trifluoroquinoline (CAS 212554-34-2)
- Tert-butyl 4-carbamoyl-4-(4-fluorobenzyl)piperidine-1-carboxylate (CAS 906329-65-5)
- Semaglutide impurity 64 (CAS CATO-C4X-222664)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com