Dextromethorphan EP Impurity A Hydrochloride CAS 1087-69-0
| CAS No. | 1087-69-0 |
| Molecular Formula | C17H23NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Dextromethorphan EP Impurity A Hydrochloride.
Dextromethorphan EP Impurity A Hydrochloride (CAS 1087-69-0) is a certified pharmaceutical impurity reference standard with the molecular formula C17H23NOHCl and a molecular weight of 293.83 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Dextromethorphan EP Impurity A Hydrochloride is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 293.83 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H23NO HCl |
| Molecular Weight | 293.83 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Dextromethorphan Standards
- Dextromethorphan impurity 41 (CAS 1058187-40-8)
- Dextromethorphan N-Oxide（HCl） (CAS 1177419-85-0)
- Dextromethorphan N-Oxide (CAS 1177494-18-6)
- Dextromethorphan Impurity 3-methoxy-17-methyl-morphinan-10β-ol Formic acid (CAS 120442-81-1（free base）)
- Dextromethorphan (CAS 125-69-9)
- Dextromethorphan impurity 23 (CAS 125-70-2)
- Dextromethorphan EP Impurity B (CAS 125-73-5)
- Dextromethorphan-d3 HBr (CAS 1279034-15-9)
Recommended Standards
- Upadacitinib Impurity 183 (CAS 2500633-42-9)
- Selexipag Impurity 42 (CAS CATO-C4X-196142)
- Vildagliptin Impurity 78 (CAS 2246354-69-6)
- 4-(4-Bromophenyl)-6-(m-tolyl)-4,5-dihydropyridazin-3(2H)-one (CAS 339013-71-7)
- 2-(Boc-amino)-2-(3,4-dichlorophenyl)acetic Acid (CAS 142121-95-7)
- 1-(2,2-Difluoroethoxy)-2-iodobenzene (CAS 1160495-81-7)
- Methyl 5-((2-chloro-5-methylphenoxy)methyl)furan-2-carboxylate (CAS 832740-67-7)
- 1-(1-Phenyl-ethyl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole (CAS 1430750-33-6)
- 1,2,3,4,6-penta-O-trimethylacetyl-β-D-glucopyranose (CAS 81058-26-6)
- Tirzepatide Impurity 23 X TFA Salt (CAS CATO-C4X-324023)
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