1-(2,2-Difluoroethoxy)-2-iodobenzene CAS 1160495-81-7
| CAS No. | 1160495-81-7 |
| Molecular Formula | C8H7F2IO |
| Molecular Weight | 284.04 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(2,2-Difluoroethoxy)-2-iodobenzene.
CATO supplies 1-(2,2-Difluoroethoxy)-2-iodobenzene (CAS 1160495-81-7), a certified reference material (molecular formula C8H7F2IO, MW 284.04 g/mol) for analytical method development and quality control.
Owing to a hydroxyl group, an ether linkage, fluorine/iodine substitution, an aromatic ring system, 1-(2,2-Difluoroethoxy)-2-iodobenzene is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 284.04 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7F2IO |
| Molecular Weight | 284.04 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F/I-containing |
Related Difluoroethoxy Standards
- 4-(2,2-Difluoroethoxy)phenylboronic Acid Pinacol Ester (CAS 864754-48-3)
- 1-(2,2-difluoroethoxy)-4-nitro-2-(trifluoromethyl)benzene (CAS 1803589-91-4)
- 4-(2,2-Difluoroethoxy)naphthalene-1-sulfonyl chloride (CAS 1184189-21-6)
- 4-(2,2-difluoroethoxy)-5-methoxy-2-nitrobenzaldehyde (CAS 1183251-26-4)
- 2-[[4-(2,2-Difluoroethoxy)benzoyl]amino]acetic acid (CAS 921623-05-4)
- 2-(2,2-difluoroethoxy)pyridine-3-sulfonyl chloride (CAS 1565428-15-0)
- 4-(2,2-Difluoroethoxy)benzene-1-sulfonyl chloride (CAS 954369-07-4)
- 4-(2,2-Difluoroethoxy)-3-trifluoromethylbenzaldehyde (CAS 1486100-65-5)
Recommended Standards
- 4,7-Dichloro-8-fluoro-2-(trifluoromethyl)quinoline (CAS 1150164-86-5)
- 2-(Difluoromethoxy)-4-iodo-1-methylbenzene (CAS 1201196-39-5)
- 1-(Difluoromethoxy)-4-iodo-2-methylbenzene (CAS 1062613-63-1)
- 4-(Difluoromethoxy)-2-iodo-1-methylbenzene (CAS 1261453-69-3)
- 1,5-naphthyridine-4-carbaldehyde (CAS 64379-44-8)
- 4-Chloro-5-methyl-2-propylpyrimidine (CAS 1708288-56-5)
- 4-METHYL-3-(HYDROXYMETHYL)MORPHOLINE HCL (CAS 1956379-95-5)
- 2-(3-Bromoadamantan-1-yl)-N-(2-((2,6-dichlorophenyl)amino)-2-oxoethyl)-N-methylacetamide (CAS 956910-01-3)
- 9-(4-Bromophenyl)-9-phenylfluorene (CAS 937082-81-0)
- 8-Bromo-6-fluoro-1,2,3,4-tetrahydro-2-naphthalenol (CAS 913296-70-5)
- 1-(methylsulfonyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-ly)-1H-Pyrrolo[2,3-b]pyridine (CAS 849068-22-0)
- Biotin-PEG3-CH2COOH (CAS 1189560-96-0)
- 4-Amino-6-chloropicolinonitrile (CAS 1206249-10-6)
- Fibrinopeptide A, human TFA (CAS 61533-47-9)
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