Estrone impurity 6 CAS 1089-80-1
| CAS No. | 1089-80-1 |
| Molecular Formula | C18H20O2 |
| Molecular Weight | 268.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Estrone impurity 6 (C18H20O2) contains a steroid core, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 268.35 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies Estrone impurity 6 (CAS 1089-80-1), a pharmacopoeial impurity reference standard (molecular formula C18H20O2, MW 268.35 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Estrone impurity 6 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H20O2 |
| Molecular Weight | 268.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Estrone Standards
- Estrone Impurity N91 (CAS 474-87-3)
- Estrone Impurity 9 (CAS CATO-C4X-21059)
- Estrone-2,4-d2 (CAS 350820-16-5)
- Estrone-d2 (CAS 56588-58-0)
- Estrone-d4 (Estriol EP Impurity B-d4) (CAS 53866-34-5)
- Estrone 3,4-quinone (CAS 40551-34-6)
- Estrone 3-Methyl Ether (CAS 1624-62-0)
- Estrone Impurity 10 (CAS CATO-C4X-210510)
Recommended Standards
- Eugenol Impurity 10 (CAS CATO-C4X-198910)
- Benzylpenicillin Impurity 72 (CAS CATO-C4X-189972)
- Avatrombopag Impurity 67 (CAS 901314-75-8)
- Oseltamivir impurity 281 (CAS CATO-C4X-1720281)
- Linezolid Impurity 29 (CAS 496031-57-3)
- Propofol Impurity 34 (CAS 40946-46-1)
- Bupivacaine Impurity 28 (CAS 2125994-25-2)
- (1-(5-Fluoro-2-methylphenyl)-1H-1,2,3-triazol-4-yl)methanamine (CAS 1251109-56-4)
- tert-Butyl 1-amino-3-azabicyclo[3.2.1]octane-3-carboxylate (CAS 1780781-02-3)
- Tolvaptan Impurity 94 (CAS CATO-C4X-195594)
- 7,8-Dichloro-4-hydroxyquinoline-3-carbonitrile (CAS 61338-32-7)
- 365462-24-4 Darexaban Maleate N-[2-[[4-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)benzoyl]amino]-3-hydroxyphenyl]-4-methoxybenzamide (2Z)-2-Butenedioate (CAS 365462-24-4)
- 2-(Methylsulfonyl)pyridin-4-amine (CAS 944401-88-1)
- Semaglutide Impurity 184 (CAS CATO-C4X-2226184)
Why CATO?
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- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com