Estrone-d4 (Estriol EP Impurity B-d4) CAS 53866-34-5
| CAS No. | 53866-34-5 |
| Molecular Formula | - |
| Molecular Weight | 274.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Estrone-d4 (Estriol EP Impurity B-d4) (C18H18D4O2) contains deuterium isotope labeling, a steroid core, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 274.39 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Estrone-d4 (Estriol EP Impurity B-d4) (CAS 53866-34-5, C18H18D4O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H18D4O2 |
| Molecular Weight | 274.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
Related Estrone Standards
Recommended Standards
- 2-tert-Butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine 2-tert-Butylimino-2-diethylamino-1,3-dimethylperhydro-1,3,2-diazaphosphorine solution 98015-45-3 BEMP (CAS 98015-45-3)
- Hexestrol-D4 (CAS 1189950-25-1)
- 17β-Dihydroequilin-2,4,16,16-d4 (CAS 350819-99-7)
- 17β-Estradiol-2,4-d2 (CAS 53866-33-4)
- Upadacitinib Impurity 126 (CAS CATO-C4X-2405126)
- Brivaracetam Impurity 181 (CAS CATO-C4X-2007181)
- Nebivolol Impurity 28 (CAS 112068-01-6)
- 1,3-Difluoro-5-vinylbenzene (CAS 182132-57-6)
- n-(Pyrimidin-5-ylmethyl)hexan-1-amine (CAS 1344211-64-8)
- 2-[(4-Chlorophenyl)sulfanyl]-2-methylpropanal (CAS 56421-90-0)
- tert-Butyl 3-oxo-2,6,7,8-tetrahydropyrido[3,2-c]pyridazine-5(3H)-carboxylate (CAS 1701807-80-8)
- tert-Butyl 6-oxoheptanoate (CAS 116666-94-5)
- 4-(((1-Isopropyl-1H-pyrazol-5-yl)methyl)amino)butan-1-ol hydrochloride (CAS 1856045-69-6)
- Anorexigenic Peptide (CAS 69275-10-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com