Propofol Impurity 34 CAS 40946-46-1
| CAS No. | 40946-46-1 |
| Molecular Formula | C11H12O5 |
| Molecular Weight | 224.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Propofol Impurity 34 (CAS 40946-46-1) is a certified pharmaceutical impurity reference standard with the molecular formula C11H12O5 and a molecular weight of 224.21 g/mol.
The molecular framework of Propofol Impurity 34 (C11H12O5) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H12O5 |
| Molecular Weight | 224.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1968 |
Related Propofol Standards
- Propofol Impurity 21 (CAS 153752-00-2)
- Propofol EP Impurity N (CAS 13423-73-9)
- Propofol Impurity 32 (CAS 161070-01-5)
- Propofol Impurity 33 (CAS CATO-C4X-147333)
- Propofol Impurity 35 (CAS 2215-21-6)
- Propofol Impurity 39 (CAS 100482-27-7)
- Propofol Impurity 46 (CAS CATO-C4X-147346)
- Propofol Impurity 48 (CAS CATO-C4X-147348)
Recommended Standards
- Ketoprofen Impurity 53 (CAS 1420774-68-0)
- Stavudine(Zidovudine EP Impurity A) (CAS 3056-17-5)
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- Acipimox Impurity 13 (CAS CATO-C4X-186613)
- Tenofovir Alafenamide Impurity 18 (CAS 379270-35-6)
- Milnacipran impurity 30 (CAS 115373-42-7)
- Phenylephrine Impurity N21 (CAS 2292095-11-3)
- Propofol Impurity 21 (CAS 83237-15-4)
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