Linagliptin Impurity 32 CAS 109113-72-6
| CAS No. | 109113-72-6 |
| Molecular Formula | C10H9ClN2 |
| Molecular Weight | 192.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Linagliptin Impurity 32 (CAS 109113-72-6, C10H9ClN2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Linagliptin Impurity 32 (C10H9ClN2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Linagliptin Impurity 32 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H9ClN2 |
| Molecular Weight | 192.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Linagliptin Standards
- Linagliptin Impurity 126 (CAS CATO-C4X-1101126)
- Linagliptin Impurity 27 (CAS 56700-70-0)
- Linagliptin Impurity 37 (CAS 216854-23-8)
- Linagliptin Impurity 39 (CAS 184637-48-7)
- Linagliptin Impurity 53 (CAS 188111-79-7)
- Linagliptin Impurity 75 (CAS 14785-95-6)
- Linagliptin Impurity 51 (CAS 6640-59-1)
- Linagliptin Impurity 54 (CAS 13535-91-6)
Recommended Standards
- 89793-11-3 A19277 Methyl2-chloro-6-methylpyrimidine-4-carboxylate methyl 2-chloro-6-methylpyrimidine-4-carboxylate (CAS 89793-11-3)
- Lercanidipine Impurity 56 (CAS CATO-C4X-136456)
- 3-CARBOXY-5-CHLOROANISOLE 3-chloro-5-methoxybenzoic acid 5-CHLORO-M-ANISIC ACID 82477-67-6 AS06305 (CAS 82477-67-6)
- Lercanidipine Impurity 57 (CAS CATO-C4X-136457)
- Finerenone Impurity 188 (CAS CATO-C4X-2880188)
- Cinepazide Impurity 12 (CAS 10263-19-1)
- Galantamine EP Impurity D (CAS 664995-65-7)
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- tert-Butyl 2-carbamothioyl-4-phenylpyrrolidine-1-carboxylate (CAS 885277-70-3)
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- 2,5-Diethoxycyclohexa-2,5-diene-1,4-dione (CAS 20765-04-2)
- 4-Bromo-N-[(4-methoxyphenyl)methyl]benzenesulfonamide (CAS 329939-43-7)
- [5-31]-Semaglutide (CAS CATO-C4X-2226263)
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