Linagliptin Impurity 27 CAS 56700-70-0
| CAS No. | 56700-70-0 |
| Molecular Formula | C10H14N2O2 |
| Molecular Weight | 194.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Linagliptin Impurity 27.
CATO supplies Linagliptin Impurity 27 (CAS 56700-70-0), a pharmacopoeial impurity reference standard (molecular formula C10H14N2O2, MW 194.23 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Linagliptin Impurity 27 (C10H14N2O2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Linagliptin Impurity 27 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H14N2O2 |
| Molecular Weight | 194.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Nitrogen Atoms | 2 |
Related Linagliptin Standards
- Linagliptin Impurity 32 (CAS 109113-72-6)
- Linagliptin Impurity 126 (CAS CATO-C4X-1101126)
- Linagliptin Impurity 37 (CAS 216854-23-8)
- Linagliptin Impurity 39 (CAS 184637-48-7)
- Linagliptin Impurity 53 (CAS 188111-79-7)
- Linagliptin Impurity 75 (CAS 14785-95-6)
- Linagliptin Impurity 51 (CAS 6640-59-1)
- Linagliptin Impurity 17 (CAS 6140-11-0)
Recommended Standards
- Vildagliptin Impurity 40 (CAS 19943-27-2)
- Amoxicillin Impurity 41 (CAS CATO-C4X-114841)
- Vildagliptin Impurity 39 (CAS 6708-06-1)
- Ramosetron impurity 32 (CAS 167545-91-7)
- Entecavir Impurity 19 (CAS 1030919-51-7)
- Eltrombopag Impurity 118 (CAS CATO-C4X-1198118)
- Sulbactam EP Impurity F (CAS 24158-88-1)
- N-(2-chlorophenyl)-2-((3-chlorophenyl)sulfinyl)acetamide (CAS 339107-05-0)
- 5-(Pyridin-4-yl)-6-(trifluoromethyl)pyridin-2-ol (CAS 1214342-18-3)
- (R)-4-((S)-1-hydroxyethyl)-1-((S)-1-(4-methoxyphenyl)ethyl)pyrrolidin-2-one (CAS 1319738-37-8)
- 1-[(2-Chloro-6-fluorophenyl)methyl]-3-[(2,6-dichlorophenyl)methoxy]-2-methyl-1,4-dihydropyridin-4-one (CAS 338965-33-6)
- 4-Cyclopropyl-2-((ethylthio)methyl)pyrimidine-5-carboxylic acid (CAS 1488261-24-0)
- 4-(4-Bromobenzyl)tetrahydro-2h-pyran-4-amine hydrochloride (CAS 1385696-37-6)
- Semaglutide impurity 103 (CAS 1446013-07-5)
Why CATO?
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com