Docetaxel Impurity 48 CAS 1095547-90-2
| CAS No. | 1095547-90-2 |
| Molecular Formula | C43H53NO15 |
| Molecular Weight | 823.88 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Docetaxel Impurity 48 (CAS 1095547-90-2) is a certified pharmaceutical impurity reference standard with the molecular formula C43H53NO15 and a molecular weight of 823.88 g/mol.
The molecular framework of Docetaxel Impurity 48 (C43H53NO15) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), Docetaxel Impurity 48 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C43H53NO15 |
| Molecular Weight | 823.88 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 1 |
Related Docetaxel Standards
- Docetaxel Impurity 63 (CAS CATO-C4X-161963)
- Docetaxel Impurity 61 (CAS 157067-34-0)
- Docetaxel-d9 (CAS 940867-25-4)
- Docetaxel (Anhydrous) (CAS 114977-28-5)
- Docetaxel EP Impurity C (CAS 153381-68-1)
- Docetaxel Impurity 49 (CAS 1095547-86-6)
- Docetaxel Impurity 62 (CAS CATO-C4X-161962)
- Docetaxel Impurity 77 (CAS CATO-C4X-161977)
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