Xylometazoline EP Impurity F CAS 854646-92-7
| CAS No. | 854646-92-7 |
| Molecular Formula | C14H20O2 |
| Molecular Weight | 220.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Xylometazoline EP Impurity F (CAS 854646-92-7), a pharmacopoeial impurity reference standard (molecular formula C14H20O2, MW 220.31 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Xylometazoline EP Impurity F (C14H20O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 220.31 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H20O2 |
| Molecular Weight | 220.31 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at room temperature |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
Related Xylometazoline Standards
- Xylometazoline EP Impurity B (CAS 19387-83-8)
- Xylometazoline Impurity 9 (CAS 1260490-37-6)
- Xylometazoline EP Impurity C (CAS 84803-57-6)
- Xylometazoline EP Impurity A (CAS 94266-17-8)
- Xylometazoline EP Impurity E (CAS 104-15-4)
- Xylometazoline Impurity 8 (CAS 1260490-36-5)
- Xylometazoline Impurity N1 (CAS 7364-19-4)
- Xylometazoline EP Impurity A (CAS 81201-80-1)
Recommended Standards
- Lidocaine EP Impurity G (CAS 42459-30-3)
- Tetracaine impurity 20 (CAS 1152620-27-3)
- Lidocaine EP Impurity K (CAS 74634-66-5)
- Prilocaine Impurity 16 (CAS 768298-27-7)
- Leflunomide EP Impurity B (Teriflunomide) (CAS 163451-81-8)
- Lipoic acid impurity 15 (CAS CATO-C4X-151815)
- Selamectin Impurity A (CAS CATO-C4X-21154)
- (3-Fluoro-4-methoxyphenyl)(7-(thiophen-2-yl)-1,4-thiazepan-4-yl)methanone (CAS 1706183-49-4)
- 3-[2-Chloro-4-(tert-pentyl)phenoxy]azetidine (CAS 1220021-39-5)
- 4-Chloro-2-[(1-methylpiperidin-4-yl)amino]benzonitrile (CAS 939816-96-3)
- Phenol, 4-(4-methyl-1-piperazinyl)- (CAS 163210-63-7)
- 5-Chlorothiophene-2-carbonyl Chloride (CAS 42518-98-9)
- 4-Methacryloxyethyl trimellitic anhydride (CAS 70293-55-9)
- Semaglutide Impurity 124 (CAS CATO-C4X-2226124)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com