Ibrutinib Impurity 158 CAS CATO-C4X-1064158
| CAS No. | CATO-C4X-1064158 |
| Molecular Formula | C20H16ClN5O2 |
| Molecular Weight | 393.83 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Ibrutinib Impurity 158 (CAS CATO-C4X-1064158), a pharmacopoeial impurity reference standard (molecular formula C20H16ClN5O2, MW 393.83 g/mol) used for the identification and quantification of trace impurities in APIs.
Ibrutinib Impurity 158 (C20H16ClN5O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO manufactures Ibrutinib Impurity 158 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H16ClN5O2 |
| Molecular Weight | 393.83 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Ibrutinib Standards
- Ibrutinib Impurity 129 (CAS CATO-C4X-1064129)
- Ibrutinib Impurity 35 (CAS CATO-C4X-106435)
- Ibrutinib Impurity 174 (CAS CATO-C4X-1064174)
- Ibrutinib Impurity 136 (CAS 2190506-59-1)
- Ibrutinib Impurity 140 (CAS CATO-C4X-1064140)
- Ibrutinib Impurity 10 (CAS 1022150-12-4)
- Ibrutinib Impurity 24 (CAS 330785-90-5)
- Ibrutinib Impurity 25 (CAS CATO-C4X-106425)
Recommended Standards
- tert-butyl 1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl(methyl)carbamate (CAS 1420983-60-3)
- Vosilasarm (CAS 1182367-47-0)
- Tert-butyl 4-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)(methyl)amino)piperidine-1-carboxylate (CAS 1417793-99-7)
- Methyl 4-(2-(2-((4-chlorophenyl)carbamothioyl)hydrazinyl)-2-oxoethoxy)benzoate (CAS 1024147-43-0)
- Tosufloxacin Impurity 1 DiHCl (CAS 103831-11-4)
- Dotinurad Impurity 196 (CAS CATO-C4X-2494196)
- Biotin Impurity 21 HBr (CAS 412308-26-0（free base）)
- 3-(3-Chlorophenyl)-6,7-dimethoxyquinazoline-2,4(1H,3H)-dione (CAS 364748-38-9)
- N-methoxy-N-methyl-1,2,3,6-tetrahydropyridine-2-carboxamide hydrochloride (CAS 1823182-24-6)
- N-[2-(2-Amino-benzoimidazol-1-yl)-ethyl]-acetamide (CAS 789434-41-9)
- methyl 5-bromo-2-chloro-4-methylbenzoate (CAS 1695248-17-9)
- 1-(5-Bromonaphthalen-1-yl)cyclopropane-1-carboxylic acid (CAS 1781079-61-5)
- 6-Chloro-2-(methylthio)-5-nitropyrimidin-4-amine (CAS 38136-96-8)
- D-[Thr]5-Semaglutide (CAS CATO-C4X-2226245)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com