Ibrutinib Impurity 53 CAS 109831-68-7
| CAS No. | 109831-68-7 |
| Molecular Formula | C5H6N4O |
| Molecular Weight | 138.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 138.13 g/mol gives Ibrutinib Impurity 53 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Ibrutinib Impurity 53 (CAS 109831-68-7, C5H6N4O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C5H6N4O, Ibrutinib Impurity 53 contains an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 138.13 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H6N4O |
| Molecular Weight | 138.13 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1988 |
| Nitrogen Atoms | 4 |
Related Ibrutinib Standards
- Ibrutinib Impurity 58(stabilized with MEHQ) (CAS 2051-76-5)
- Ibrutinib Impurity 55 (CAS 5399-92-8)
- Ibrutinib Impurity 156 (CAS 1642601-01-1)
- Ibrutinib Impurity 57 (CAS 24211-55-0)
- Ibrutinib Impurity 52 (CAS 50717-82-3)
- Ibrutinib Impurity 54 (CAS 1260862-85-8)
- Ibrutinib Impurity N2 (CAS 43191-23-7)
- Ibrutinib Impurity 98 (CAS CATO-C4X-106498)
Recommended Standards
- Telmisartan Impurity N4 (CAS 89323-10-4)
- Cefminox Impurity 14 (CAS 51138-06-8)
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- (R)-4-Methyl-1,3,2-dioxathiolane 2,2-dioxide (CAS 1006381-03-8)
- Leflunomide Impurity 24 (CAS CATO-C4X-167324)
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- 3-Fluoro-5-(methoxycarbonyl)pyrazolo[1,5-a]pyrimidine-7-carboxylic acid (CAS 916212-03-8)
- Hexanoic acid, 6-[(2,5-dioxo-1-pyrrolidinyl)oxy]-6-oxo-, ethyl ester (CAS 192225-64-2)
- 4-Bromo-1-cyclopropyl-1H-pyrazole-5-carbaldehyde (CAS 1512687-78-3)
- Topiramate Impurity 37 (CAS 851957-35-2)
- Prolactin-Releasing Peptide (1-31) (rat) (CAS 215510-06-8)
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