Ibrutinib Impurity 58(stabilized with MEHQ) CAS 2051-76-5
| CAS No. | 2051-76-5 |
| Molecular Formula | C6H6O3 |
| Molecular Weight | 126.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Ibrutinib Impurity 58(stabilized with MEHQ) is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Ibrutinib Impurity 58(stabilized with MEHQ) (CAS 2051-76-5, C6H6O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system, Ibrutinib Impurity 58(stabilized with MEHQ) is typically off-white to pale yellow liquid. Its solid-state physicochemical attributes — including a molecular weight of 126.11 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ibrutinib Impurity 58(stabilized with MEHQ) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H6O3 |
| Molecular Weight | 126.11 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Ibrutinib Standards
- Ibrutinib Impurity 53 (CAS 109831-68-7)
- Ibrutinib Impurity 57 (CAS 24211-55-0)
- Ibrutinib Impurity 52 (CAS 50717-82-3)
- Ibrutinib Impurity 55 (CAS 5399-92-8)
- Ibrutinib Impurity 156 (CAS 1642601-01-1)
- Ibrutinib Impurity 54 (CAS 1260862-85-8)
- Ibrutinib Impurity N2 (CAS 43191-23-7)
- Ibrutinib Impurity 98 (CAS CATO-C4X-106498)
Recommended Standards
- Vonoprazan Impurity 139 (CAS CATO-C4X-1020139)
- Dapagliflozin Impurity 134 (CAS CATO-C4X-1138134)
- Furyl Hydroxymethyl Ketone (CAS 17678-19-2)
- Zidovudine EP Impurity C (CAS 65-71-4)
- Dapagliflozin Impurity 190 (CAS CATO-C4X-1138190)
- Formoterol Impurity 62 (CAS CATO-C4X-152562)
- Vildagliptin Impurity 106 (CAS CATO-C4X-1100106)
- Ethyl 4-((6-hydroxy-7-methyl-2-oxo-2H-chromen-4-yl)methyl)piperazine-1-carboxylate (CAS 859859-66-8)
- MY33-3 (hydrochloride) (CAS 2204280-42-0)
- 2-Chloro-5-ethyl-1,3,4-thiadiazole (CAS 71859-81-9)
- 2-(1-Methylhydrazinyl)-4-(trifluoromethyl)pyrimidine (CAS 1372711-01-7)
- 1-(2-Fluorophenyl)-2-(trifluoromethoxy)ethan-1-amine (CAS 1334147-38-4)
- 3-Methylhexyl acetate (CAS 50373-54-1)
- Gastric Inhibitory Polypeptide (3-42) (human) trifluoroacetate salt (CAS 1802086-25-4)
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