Lusutrombopag Impurity N1 CAS 1110767-96-8
| CAS No. | 1110767-96-8 |
| Molecular Formula | C17H25ClO3 |
| Molecular Weight | 312.83 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Lusutrombopag Impurity N1 (CAS 1110767-96-8, C17H25ClO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Lusutrombopag Impurity N1 (C17H25ClO3) contains a steroid core, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 312.83 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H25ClO3 |
| Molecular Weight | 312.83 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | Cl-containing |
Related Lusutrombopag Standards
- Lusutrombopag Impurity 10 (CAS CATO-C4X-208410)
- Lusutrombopag Impurity 11 (CAS CATO-C4X-208411)
- Lusutrombopag Impurity 18 (CAS 1110767-94-6)
- Lusutrombopag Impurity 68 (CAS CATO-C4X-208468)
- Lusutrombopag Impurity 30 (CAS 1110767-19-5)
- Lusutrombopag Impurity 87 (CAS CATO-C4X-208487)
- Lusutrombopag Impurity N3 (CAS 1110767-89-9)
- Lusutrombopag Impurity 47 (CAS CATO-C4X-208447)
Recommended Standards
- 3-Chloro-4-decyloxybenzoic acid (CAS 106316-08-9)
- Iridium(2+),pentaamminechloro-,(OC-6-22)- (CAS 29589-09-1)
- Mcpa-2-Ethylhexyl Ester (CAS 29450-45-1)
- 4-Chloro-6-[(4-methylphenyl)sulfanyl]-3-phenylpyridazine (CAS 477872-27-8)
- Deferiprone Impurity 4 HCl (CAS CATO-C4X-30484)
- Apalutamide Impurity 116 (CAS CATO-C4X-2749116)
- Macitentan Impurity 24 (CAS 556797-16-1)
- 4-Butyl-1-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS 1002334-09-9)
- 7-(Chloromethyl)benzo[d]thiazole (CAS 688732-17-4)
- Latamoxef Impurity 28 (CAS CATO-C4X-179828)
- 2-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)thiazole (CAS 1314390-00-5)
- 4-Chloro-3,7-dihydro-1H-pyrrolo[2,3-b]pyridine-2,6-dione (CAS 1190313-44-0)
- (3-Fluoro-5-methylpyridin-4-yl)methanol (CAS 1803849-16-2)
- Semaglutide Impurity 150 xTFA (CAS CATO-C4X-2226150)
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