Macitentan Impurity 24 CAS 556797-16-1
| CAS No. | 556797-16-1 |
| Molecular Formula | C20H21Br2N5O4S |
| Molecular Weight | 587.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 587.28 g/mol gives Macitentan Impurity 24 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Macitentan Impurity 24 (CAS 556797-16-1) is a certified pharmaceutical impurity reference standard with the molecular formula C20H21Br2N5O4S and a molecular weight of 587.28 g/mol.
Owing to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, bromine substitution, Macitentan Impurity 24 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 587.28 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H21Br2N5O4S |
| Molecular Weight | 587.28 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Macitentan Standards
- Macitentan (CAS 441798-33-0)
- Macitentan Impurity 26 (CAS CATO-C4X-117526)
- Macitentan-d4 (CAS 1258428-05-5)
- Macitentan Impurity 2 (CAS 441796-13-0)
- Macitentan Impurity 27 (CAS CATO-C4X-117527)
- Macitentan Impurity 22 (CAS CATO-C4X-117522)
- Macitentan Impurity 23 (CAS CATO-C4X-117523)
- Macitentan Impurity 1 (CAS 441798-25-0)
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- (S)-2-(2-chloro-6-fluoro-3-methylphenyl)pyrrolidine (CAS 1213020-45-1)
- 4,5-Dibromo-1,3-thiazole (CAS 67594-67-6)
- Pyrrolidine-1-carbothioamide (CAS 40398-36-5)
- Semaglutide impurity 67 (CAS CATO-C4X-222667)
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