Temozolomide Impurity 22 CAS 1114912-01-4
| CAS No. | 1114912-01-4 |
| Molecular Formula | C4HN5 |
| Molecular Weight | 119.08 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Temozolomide Impurity 22 is closely related to a nitrile group in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Temozolomide Impurity 22 (CAS 1114912-01-4) is a certified pharmaceutical impurity reference standard with the molecular formula C4HN5 and a molecular weight of 119.08 g/mol.
The molecular framework of Temozolomide Impurity 22 (C4HN5) is characterized by a nitrile group. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C4HN5 |
| Molecular Weight | 119.08 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 5 |
Related Temozolomide Standards
- Temozolomide Impurity 14 (CAS 57052-92-3)
- Temozolomide Impurity 23 (CAS 360-97-4)
- Temozolomide Impurity 18 (CAS 4919-04-4)
- Temozolomide Impurity 16 (CAS 20344-79-0)
- Temozolomide Impurity 20 (CAS 18514-52-8)
- Temozolomide Impurity 16 (CAS 71749-37-6)
- Temozolomide EP Impurity D (CAS 7008-85-7)
- Temozolomide Impurity 10 (CAS 90801-87-9)
Recommended Standards
- 2483-57-0 Nitroacetic acid methyl ester Acetic acid, nitro-, methyl ester Methyl nitroacetate 4-02-00-00537 (Beilstein Handbook Reference) BRN 1758670 EINECS 219-622-0 Methyl 2-nitroacetate NSC 16153 (CAS 2483-57-0)
- 3-Nitropropionic Acid (CAS 504-88-1)
- (Z)-4-amino-2-fluorobut-2-enoic acid (CAS 113779-23-0)
- Hadacidin (CAS 689-13-4)
- Naftopidil Impurity 1 (CAS 2461-42-9)
- Tirofiban Impurity 97 (CAS CATO-C4X-125497)
- Tebipenem Impurity 8 (CAS 161715-27-1)
- N-methylcinnolin-4-amine (CAS 16401-71-1)
- (4S,5S)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one (CAS 875444-06-7)
- Ethyl 2-(2-((4-methoxybenzyl)sulfonyl)-4,5-diphenyl-1H-imidazol-1-yl)acetate (CAS 339277-84-8)
- N-(1,3-Benzodioxol-5-ylmethyl)-2-(1H-indol-3-yl)ethanamine (CAS 51918-89-9)
- Axitinib Impurity N25 (CAS 1266386-30-4)
- (S)-2-Amino-N-methyl-N-(4-methylbenzyl)propanamide (CAS 1307127-20-3)
- Insulin Detemir (CAS 169148-63-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com