Temozolomide Impurity 18 CAS 4919-04-4
| CAS No. | 4919-04-4 |
| Molecular Formula | C4H5N3O2 |
| Molecular Weight | 127.10 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Temozolomide Impurity 18 is closely related to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Temozolomide Impurity 18 (CAS 4919-04-4, C4H5N3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C4H5N3O2, Temozolomide Impurity 18 contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 127.10 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Temozolomide Impurity 18 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C4H5N3O2 |
| Molecular Weight | 127.10 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 3 |
Related Temozolomide Standards
- Temozolomide Impurity 23 (CAS 360-97-4)
- Temozolomide Impurity 14 (CAS 57052-92-3)
- Temozolomide Impurity 22 (CAS 1114912-01-4)
- Temozolomide Impurity 16 (CAS 71749-37-6)
- Temozolomide EP Impurity D (CAS 7008-85-7)
- Temozolomide Impurity 10 (CAS 90801-87-9)
- Temozolomide Impurity 16 (CAS 20344-79-0)
- Temozolomide Impurity 20 (CAS 18514-52-8)
Recommended Standards
- Dexmedetomidine Impurity 80 (CAS CATO-C4X-123080)
- Tinidazole EP Impurity A (CAS 696-23-1)
- Tofacitinib Impurity 117 (CAS 873-83-6)
- Metronidazole Impurity 11 (CAS 3034-41-1)
- Atogepant Impurity 45 (CAS CATO-C4X-328545)
- Dalilesen Impurity 30 (CAS 2248726-39-6)
- Semaglutide impurity 277 (CAS CATO-C4X-2226277)
- N-(2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide (CAS 1638329-59-5)
- 3,3-Dimethyl-2-(2-tetrahydrofuryl)azetidine (CAS 1803607-84-2)
- 4-Fluoro-2-({[(oxolan-2-yl)methyl]amino}methyl)phenol (CAS 1522538-33-5)
- 4-(Fluorosulfonyl)thiophene-2-carboxylic acid (CAS 1384428-37-8)
- 2-Bromo-6-methylpyrimidine-4-carbonitrile (CAS 1698473-34-5)
- (2R,5R)-L-Menthyl-5-(acetyloxy)-1,3-oxathiolane-2-carboxylate (CAS 147027-09-6)
- D-Ala28-Tirzepatide (CAS CATO-CPTD788906)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com