Baloxavir Marboxil Impurity 218 CAS 111608-81-2
| CAS No. | 111608-81-2 |
| Molecular Formula | C8H4F2O3 |
| Molecular Weight | 186.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, Baloxavir Marboxil Impurity 218 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 186.11 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Baloxavir Marboxil Impurity 218 (CAS 111608-81-2) is a certified pharmaceutical impurity reference standard with the molecular formula C8H4F2O3 and a molecular weight of 186.11 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H4F2O3 |
| Molecular Weight | 186.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1988 |
| Halogen Content | F-containing |
Related Baloxavir Standards
- Baloxavir Marboxil Impurity 223 (CAS CATO-C4X-2108223)
- Baloxavir Marboxil Impurity 229 (CAS CATO-C4X-2108229)
- Baloxavir Marboxil Impurity 238 (CAS CATO-C4X-2108238)
- Baloxavir Marboxil Impurity 219 (CAS CATO-C4X-2108219)
- Baloxavir Impurity 25 (CAS 50594-94-0)
- Baloxavir Impurity 26 (CAS 207804-63-5)
- Baloxavir Impurity 60 (CAS 178461-70-6)
- Baloxavir Marboxil Impurity 163 (CAS 124948-51-2)
Recommended Standards
- D-Galactose-13C6 (CAS 74134-89-7)
- Buprenorphine Impurity 2 (CAS 2136287-63-1)
- 287100-74-7 d-mannose-ul 13c6 (CAS 287100-74-7)
- D-Glucose-13C6 (CAS 110187-42-3)
- Glucosamine EP Impurity E (CAS 67-47-0)
- Pramipexole Impurity 19 (CAS CATO-C4X-110719)
- Landiolol Impurity 58 (CAS CATO-C4X-262158)
- 5-Fluoroindole-3-acetic hydrazide (CAS 376646-57-0)
- (2-Hydroxyethyl)thiourea (CAS 29146-81-4)
- 5-bromo-4-(morpholin-4-yl)pyridin-2-amine (CAS 1220423-55-1)
- N-(3-Amino-2-methylphenyl)-4-isobutoxybenzamide (CAS 1020056-36-3)
- 3-Mercaptohexyl Acetate (CAS 136954-20-6)
- Ceritinib Impurity 21 (CAS CATO-C4X-104821)
- Neuropeptide FF (CAS 99566-27-5)
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