Buprenorphine Impurity 2 CAS 2136287-63-1
| CAS No. | 2136287-63-1 |
| Molecular Formula | C8H4F2O3 |
| Molecular Weight | 186.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Buprenorphine Impurity 2 (CAS 2136287-63-1, C8H4F2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, Buprenorphine Impurity 2 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 186.11 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H4F2O3 |
| Molecular Weight | 186.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F-containing |
Related Buprenorphine Standards
- Buprenorphine methiodide (CAS 1026987-90-5)
- Buprenorphine hydrochloride CRS - * psy (CAS 53152-21-9)
- Buprenorphine Impurity 14 (CAS 16614-59-8)
- Buprenorphine EP Impurity C (CAS 16614-60-1)
- Buprenorphine EP Impurity E (CAS 130668-48-3)
- 7-(S)-Buprenorphine (CAS 152610-73-6)
- Buprenorphine Related Compound A CII(Secondary Standards traceble to USP) (CAS 457071-73-7)
- Buprenorphine-D4 (CAS 136781-89-0)
Recommended Standards
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- D-Glucose-13C6 (CAS 110187-42-3)
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- Ethyl 3-nitroisoxazole-5-carboxylate (CAS 1224593-92-3)
- Mivacurium Chloride Impurity 7 (S-S isomer) (CAS 104758-51-2)
- Amorolfine Impurity 44 (CAS CATO-C4X-154244)
- Indobufen Impurity 3 (CAS 1379292-20-2)
- (4-Chloro-3-methylphenyl)(2-iodophenyl)methanone (CAS 951891-18-2)
- (2S,3R,4S,5R)-2-(2,2,2-trichloro-1-iminoethoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate (CAS 128377-34-4)
- Roxatidine Impurity 66 (CAS 2765350-63-6)
- 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydropyrano[4,3,2-de]quinoline hydrochloride (CAS 2304635-32-1)
- 3-Bromo-2-iodofuran (CAS 72167-52-3)
- (cis-9)-2-Hydroxyoctadecen-17-ynoic Acid (CAS 1159977-43-1)
- Liraglutide-d8 Tritrifluoroacetate (CAS CATO-C4X-199223)
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