4-(1,1-Difluoropropyl)-1-fluoro-2-(trifluoromethyl)benzene CAS 1138445-49-4
| CAS No. | 1138445-49-4 |
| Molecular Formula | C10H8F6 |
| Molecular Weight | 242.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
4-(1,1-Difluoropropyl)-1-fluoro-2-(trifluoromethyl)benzene (CAS 1138445-49-4) is a high-purity analytical reference standard with the molecular formula C10H8F6 and a molecular weight of 242.16 g/mol.
4-(1,1-Difluoropropyl)-1-fluoro-2-(trifluoromethyl)benzene (C10H8F6) contains fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C10H8F6 |
| Molecular Weight | 242.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
Related Difluoropropyl Standards
- 1-(1,1-Difluoropropyl)-2-fluoro-3-(trifluoromethyl)benzene (CAS 1138445-48-3)
- (3,3-Difluoropropyl)triethoxysilane (CAS 124598-58-9)
- 1-(2,2-difluoropropyl)pyrazolo[3,4-d]pyrimidine-6-carboxylic acid (CAS 2230521-68-1)
- 2,2-Difluoropropyl 4-methylbenzenesulfonate (CAS 1262400-01-0)
- 6-(2,2-Difluoropropyl)thieno[2,3-d]pyrimidin-4(3H)-one (CAS 2163772-41-4)
- Benzyl (3,3-difluoropropyl)carbamate (CAS 1882187-90-7)
- 2,2-Difluoropropyl trifluoromethanesulfonate (CAS 784193-15-3)
- 2-(2,2-Difluoropropyl)isoindoline-1,3-dione (CAS 1017241-19-8)
Recommended Standards
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- Methyl 5-((3-(trifluoromethyl)phenoxy)methyl)furan-2-carboxylate (CAS 438218-32-7)
- Imidodicarbonimidic acid, 1,3-dimethyl ester (CAS 25649-35-8)
- 2-Bromo-3-(trifluoromethoxy)aniline (CAS 1805474-26-3)
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- Semaglutide impurity 256 (CAS CATO-C4X-2226256)
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