1-(2,2-Difluoropropyl)-4-methylbenzene CAS 1138445-50-7
| CAS No. | 1138445-50-7 |
| Molecular Formula | C10H12F2 |
| Molecular Weight | 170.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-(2,2-Difluoropropyl)-4-methylbenzene (CAS 1138445-50-7) is a high-purity analytical reference standard with the molecular formula C10H12F2 and a molecular weight of 170.20 g/mol.
The molecular framework of 1-(2,2-Difluoropropyl)-4-methylbenzene (C10H12F2) is characterized by fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H12F2 |
| Molecular Weight | 170.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
Related Difluoropropyl Standards
- 1-(1,1-Difluoropropyl)-4-methylbenzene (CAS 1186194-63-7)
- 1-(1,1-Difluoropropyl)-2-methylbenzene (CAS 1890776-30-3)
- 4-(1,1-Difluoropropyl)aniline (CAS 1889542-64-6)
- 3-(1,1-Difluoropropyl)aniline (CAS 1893082-45-5)
- 3-(1,1-Difluoropropyl)phenol (CAS 1889731-40-1)
- 4-(1,1-Difluoropropyl)phenol (CAS 1892511-05-5)
- 3-(1,1-Difluoropropyl)pyrazin-2-amine (CAS 2088945-80-4)
- 1-(1,1-Difluoropropyl)-2-fluorobenzene (CAS 1138445-47-2)
Recommended Standards
- 2-[(4-fluorophenyl)sulfanyl]acetaldehyde (CAS 1082573-97-4)
- 2-(Difluoromethyl)-1,3,5-trimethylbenzene (CAS 103383-72-8)
- 1-(1,1-Difluoroethyl)-4-ethylbenzene (CAS 1204295-54-4)
- Arotinolol Impurity 9 (CAS 4066-41-5)
- 2,2'-((Perfluoroethane-1,2-diyl)bis(oxy))bis(2,2-difluoroacetyl fluoride) (CAS 24647-19-6)
- 2-((1-Benzylpiperidin-3-yl)oxy)acetic acid (CAS 1353961-40-6)
- 1-(4-Methoxybenzyl)-1,2-dihydro-3H-indazol-3-one (CAS 103427-61-8)
- (5-Chloro-6-(3-fluorophenyl)pyridin-3-yl)boronic acid (CAS 2225169-53-7)
- (3S)-1-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-5-yl]pyrrolidine-3-carbaldehyde (CAS 2416132-75-5)
- (2s,3s)-2-Amino-n,3-dimethylpentanamide (CAS 128633-26-1)
- ((4-(2-Methoxyphenoxy)phenyl)sulfonyl)methionine (CAS 1008965-37-4)
- 4-Cyclopropoxy-N2,N2,N5-trimethylpyridine-2,5-diamine (CAS 1243290-15-4)
- 5'-Bromo-2'-fluoro-[1,1'-biphenyl]-3-carboxylic acid (CAS 1519110-44-1)
- Glucagon (1-29) (CAS 16941-32-5)
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