Neostigmine Bromide CAS 114-80-7
| CAS No. | 114-80-7 |
| Molecular Formula | C12H19N2O2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Neostigmine Bromide (CAS 114-80-7), molecular formula C12H19N2O2Br and molecular weight 303.20 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, Neostigmine Bromide (C12H19N2O2Br) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 303.20 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H19N2O2 Br |
| Molecular Weight | 303.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Neostigmine Standards
- Neostigmine bromide Impurity 14 (CAS 14318-66-2)
- Neostigmine Impurity 24 (CAS 15799-79-8)
- Neostigmine EP Impurity C (CAS 16088-19-0)
- Neostigmine Methyl Sulfate - Impurity A (Bromide Salt) (CAS 1620-19-5)
- Neostigmine Impurity 50 (CAS 16460-28-9)
- Neostigmine Impurity 4 (CAS 19962-04-0)
- Neostigmine impurity 31 (CAS 22237-93-0（free base）)
- Neostigmine impurity 32 (CAS 23040-64-4)
Recommended Standards
- 6-((3-Methylcyclobutyl)methoxy)nicotinic acid (CAS 1394022-58-2)
- 4325-85-3 Silanol, 1,1,1-trimethyl-, 1,1',1''-triester with boric acid (H3BO3) Silanol, trimethyl-, triester with boric acid (H3BO3) (CAS 4325-85-3)
- Carbazomycin A (CAS 75139-39-8)
- 2-(4-Formyl-1h-pyrazol-1-yl)ethyl acetate (CAS 1315367-26-0)
- 5,7-Difluoro-benzo[d]thiazole, 97% (CAS 1190322-04-3)
- Cispentacin (CAS 3814-46-8)
- 1-[4-Chloro-3-(Trifluoromethyl)Phenyl]-4,5-Dihydropyrazol-3-Amine (CAS 77992-21-3)
- 2-Amino-5-bromobenzenesulfonamide hydrobromide (CAS 54734-84-8)
- 2-Cyclopropoxy-6-(trifluoromethyl)benzonitrile (CAS 1243377-24-3)
- Palmitoyl Tripeptide-1 TFA salt (CAS 2803375-47-3)
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