Neostigmine EP Impurity C CAS 16088-19-0
| CAS No. | 16088-19-0 |
| Molecular Formula | C11H16N2O2 |
| Molecular Weight | 208.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Neostigmine EP Impurity C (CAS 16088-19-0) is a certified pharmaceutical impurity reference standard with the molecular formula C11H16N2O2 and a molecular weight of 208.26 g/mol.
The molecular framework of Neostigmine EP Impurity C (C11H16N2O2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H16N2O2 |
| Molecular Weight | 208.26 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Nitrogen Atoms | 2 |
Related Neostigmine Standards
- Neostigmine impurity 35 (CAS CATO-C4X-204235)
- Neostigmine Bromide EP Impurity C-d6 (Nor Neostigmine-d6) (CAS 2470126-73-7)
- Neostigmine impurity 01 (CAS 618-09-7)
- Neostigmine Impurity 25 (CAS 76418-45-6)
- Neostigmine impurity 34 (CAS CATO-C4X-204234)
- Neostigmine impurity 36 (CAS CATO-C4X-204236)
- Neostigmine impurity 38 (CAS CATO-C4X-204238)
- Neostigmine impurity 33 (CAS CATO-C4X-204233)
Recommended Standards
- Mizolastine Impurity 5 (CAS 130212-30-5)
- Bilastine impurity 117 (CAS 926245-76-3)
- Pimavanserin impurity 57 (CAS CATO-C4X-193857)
- Chalcone (CAS 94-41-7)
- Phosphoramidite Impurity 28 (CAS 2005449-47-6)
- Tegoprazan impurity 84 (CAS CATO-C4X-229784)
- Cefixime EP Impurity B (CAS 1335475-19-8)
- 4-(Methylsulfonyl)pyridin-2(1H)-one (CAS 1268519-33-0)
- 3-(4-Chlorophenyl)-4-nitro-5-phenylisoxazole (CAS 57354-92-4)
- (-)-6-Fluoro-2,3-dihydro-1H-inden-1-amine hydrochloride (CAS 148940-94-7)
- 3-bromo-2,2-dimethylpropan-1-amine hydrobromide (CAS 1350885-39-0)
- Esomeprazole Impurity 52 (CAS 704910-88-3)
- 2-((E)-3-(5,5-Dimethyl-3-[(E)-3-(1,3,3-trimethyl-1,3-dihydro-2H-indol-2-ylidene)-1-propenyl]-2-cyclohexen-1-ylidene)-1-propenyl)-1,3,3-trimethyl-3H-indolium tetrafluoroborate 410536-44-6 536D446 (CAS 410536-44-6)
- [Tyr15] Fibrinopeptide B, human (CAS 125455-56-3)
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