Pioglitazone impurity 57 CAS 1147527-36-3
| CAS No. | 1147527-36-3 |
| Molecular Formula | C28H29N3O3S |
| Molecular Weight | 487.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, Pioglitazone impurity 57 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 487.61 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Pioglitazone impurity 57 (CAS 1147527-36-3, C28H29N3O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C28H29N3O3S |
| Molecular Weight | 487.61 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Pioglitazone Standards
- Pioglitazone impurity 52 (CAS CATO-C4X-138352)
- Pioglitazone Impurity 2 (CAS CATO-C4X-13832)
- Pioglitazone EP Impurity C (CAS 952188-00-0)
- Pioglitazone impurity 29 (CAS CATO-C4X-138329)
- Pioglitazone N-beta-D-Glucuronide (Mixture of Diastereomers) (CAS 1296832-75-1)
- Pioglitazone impurity 26 (CAS 446052-43-3)
- Pioglitazone EP Impurity F (CAS 1391052-15-5)
- Pioglitazone Thiazolidinedione Ring-opened N-β-D-Glucuronide (CAS 1296832-76-2)
Recommended Standards
- Tunodafil Impurity 10 (CAS CATO-C4X-311010)
- Yonkenafil (CAS 804518-63-6)
- 2-(4-(3-Chlorophenyl)piperazin-1-yl)-N-(2,5-dibromophenyl)acetamide (CAS 882083-72-9)
- 4-Butoxy-N-((3-(5,6-dimethylbenzo[d]oxazol-2-yl)-2-methylphenyl)carbamothioyl)benzamide (CAS 590397-26-5)
- Rebamipide Impurity 1 (CAS 94670-39-0)
- Duloxetine impurity 01 (CAS 132335-49-0)
- Olopatadine Impurity 6 (CAS CATO-C4X-17186)
- 3-[(1,3-dioxaindan-5-yl)sulfamoyl]benzoic acid (CAS 775310-75-3)
- 2-Bromo-1-(2-(trifluoromethyl)phenyl)propan-1-one (CAS 104384-69-2)
- 5-(Benzo[b]thiophen-3-yl)-4-isopropyl-4H-1,2,4-triazole-3-thiol (CAS 861433-23-0)
- 7-Ethyl-10-hydroxycamptothecin-D5 (CAS CATO-C4X-166733)
- Thioctic acid Impurity 43 (CAS 46236-19-5)
- 4-Hydroxybutyl Acrylate(stabilized with MEHQ) (CAS 2478-10-6)
- Palmitoyl Tripeptide -5 · 2 TFA (CAS 623172-56-5)
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