2-Hydroxy-4’-(trifluoromethoxy)acetophenone CAS 1148005-60-0
| CAS No. | 1148005-60-0 |
| Molecular Formula | C9H7F3O3 |
| Molecular Weight | 220.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-Hydroxy-4’-(trifluoromethoxy)acetophenone (CAS 1148005-60-0), molecular formula C9H7F3O3 and molecular weight 220.15 g/mol, is a CATO reference standard with documented purity and traceability.
2-Hydroxy-4’-(trifluoromethoxy)acetophenone (C9H7F3O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 2-Hydroxy-4’-(trifluoromethoxy)acetophenone meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H7F3O3 |
| Molecular Weight | 220.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1989 |
| Halogen Content | F-containing |
Related Hydroxy Standards
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- 2-(4-Hydroxy-3-(trifluoromethyl)phenyl)acetic acid (CAS 1042703-41-2)
- Methyl 4-hydroxy-3-(trifluoromethyl)benzoate (CAS 115933-50-1)
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- (2s)-2-Hydroxy-2-[3-(trifluoromethyl)phenyl]acetic acid (CAS 1198319-99-1)
- Methyl 2-hydroxy-5-(trifluoromethyl)benzoate (CAS 1261478-26-5)
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Recommended Standards
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